| Gene Symbol |
Mcpt4
|
| Entrez Gene |
17227
|
| Alt Symbol |
MMCP-4, MMCP-4A, MMCP-4B, Mcp-4, Mcp4
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
mast cell protease 4
|
| Other Description |
MSMCP|myonase|serosal mast cell protease
|
| Swissprots |
P21812 Q9EQT2 Q9EPQ9
|
| Accessions |
AAA72939 EDL36217 EDL36218 P21812 AB051900 BAB18732 AK144385 BAE25859 AV018388 AY007569 AAG24503 BC026198 AAH26198 CJ046459 M55617 AAA39989 X68804 CAA48704 NM_010779 NP_034909
|
| Function |
Has chymotrypsin-like activity. Hydrolyzes the amide bonds of synthetic substrates having Tyr and Phe residues at the P1 position. Preferentially hydrolyzes the 'Tyr-4-|-Ile-5' bond of angiotensin I and the 'Phe-20-|-Ala-21' bond of amyloid beta- protein, and is less active towards the 'Phe-8-|-His-9' bond of angiotensin I and the 'Phe-4-|-Ala-5' and 'Tyr-10-|-Glu-11' bonds of amyloid beta-protein. Involved in thrombin regulation and fibronectin processing. {ECO:0000269|PubMed:12900518, ECO:0000269|PubMed:9538257}.
|
| Tissue Specificity |
Submucosal mast cells. In femoral muscle, detected in myocytes but not in mast cells. {ECO:0000269|PubMed:9538257}.
|