| Gene Symbol |
NCR3
|
| Entrez Gene |
259197
|
| Alt Symbol |
1C7, CD337, LY117, MALS, NKp30
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
natural cytotoxicity triggering receptor 3
|
| Other Description |
NK-p30|activating NK-A1 receptor|activating natural killer receptor p30|lymphocyte antigen 117|natural killer cell p30-related protein
|
| Swissprots |
O95669 O14930 Q5ST89 B0S8F5 Q5ST92 O95667 O14931 Q5ST90 O95668 O14932 Q5STA3 B0S8F2 B0S8F4 Q5ST91
|
| Accessions |
AAD18088 BAB63393 CAA75063 CAA75064 CAA75065 CAA75066 CAA75067 CAA75068 EAX03439 EAX03440 EAX03441 O14931 AB055881 BAB78472 AF031136 AAB86578 AF031137 AAB86579 AF031138 AAB86580 AJ223153 CAB54004 BC018752 AAH18752 BC052582 AAH52582 BG744854 HQ447617 ADQ32103 XM_006715049 XP_006715112 XM_006725031 XP_006725094 XM_006725478 XP_006725541 XM_006725692 XP_006725755 XM_006725808 XP_006725871 XM_006725902 XP_006725965 XM_006725989 XP_006726052 XM_006726081 XP_006726144 XM_011514459 XP_011512761 XM_011546285 XP_011544587 XM_011547201 XP_011545503 XM_011547202 XP_011545504 XM_011547203 XP_011545505 XM_011547204 XP_011545506 XM_011547615 XP_011545917 XM_011547850 XP_011546152 XM_011548021 XP_011546323 XM_011548022 XP_011546324 XM_011548210 XP_011546512 XM_011548390 XP_011546692 XM_011548391 XP_011546693 XM_011548392 XP_011546694 XM_011548393 XP_011546695 NM_001145466 NP_001138938 NM_001145467 NP_001138939 NM_147130 NP_667341
|
| Function |
Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation. {ECO:0000269|PubMed:10562324, ECO:0000269|PubMed:15784725, ECO:0000269|PubMed:18852879}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:10562324}; Single-pass type I membrane protein {ECO:0000269|PubMed:10562324}.
|
| Tissue Specificity |
Selectively expressed by all resting and activated NK cells and weakly expressed in spleen. {ECO:0000269|PubMed:10562324, ECO:0000269|Ref.2}.
|
| Top Pathways |
Natural killer cell mediated cytotoxicity
|