NCR3

Gene Symbol NCR3
Entrez Gene 259197
Alt Symbol 1C7, CD337, LY117, MALS, NKp30
Species Human
Gene Type protein-coding
Description natural cytotoxicity triggering receptor 3
Other Description NK-p30|activating NK-A1 receptor|activating natural killer receptor p30|lymphocyte antigen 117|natural killer cell p30-related protein
Swissprots O95669 O14930 Q5ST89 B0S8F5 Q5ST92 O95667 O14931 Q5ST90 O95668 O14932 Q5STA3 B0S8F2 B0S8F4 Q5ST91
Accessions AAD18088 BAB63393 CAA75063 CAA75064 CAA75065 CAA75066 CAA75067 CAA75068 EAX03439 EAX03440 EAX03441 O14931 AB055881 BAB78472 AF031136 AAB86578 AF031137 AAB86579 AF031138 AAB86580 AJ223153 CAB54004 BC018752 AAH18752 BC052582 AAH52582 BG744854 HQ447617 ADQ32103 XM_006715049 XP_006715112 XM_006725031 XP_006725094 XM_006725478 XP_006725541 XM_006725692 XP_006725755 XM_006725808 XP_006725871 XM_006725902 XP_006725965 XM_006725989 XP_006726052 XM_006726081 XP_006726144 XM_011514459 XP_011512761 XM_011546285 XP_011544587 XM_011547201 XP_011545503 XM_011547202 XP_011545504 XM_011547203 XP_011545505 XM_011547204 XP_011545506 XM_011547615 XP_011545917 XM_011547850 XP_011546152 XM_011548021 XP_011546323 XM_011548022 XP_011546324 XM_011548210 XP_011546512 XM_011548390 XP_011546692 XM_011548391 XP_011546693 XM_011548392 XP_011546694 XM_011548393 XP_011546695 NM_001145466 NP_001138938 NM_001145467 NP_001138939 NM_147130 NP_667341
Function Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation. {ECO:0000269|PubMed:10562324, ECO:0000269|PubMed:15784725, ECO:0000269|PubMed:18852879}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:10562324}; Single-pass type I membrane protein {ECO:0000269|PubMed:10562324}.
Tissue Specificity Selectively expressed by all resting and activated NK cells and weakly expressed in spleen. {ECO:0000269|PubMed:10562324, ECO:0000269|Ref.2}.
Top Pathways Natural killer cell mediated cytotoxicity

NKp30 (CLH3) - sc-33646 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NKp30 (CLH3): sc-33646. Western blot analysis of NKp30 expression in transfected 293 cells.

NKp30 (CLH9) - sc-33647 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NKp30 (CLH9): sc-33647. Indirect FCM analysis of 293-rat NKp30 stable transfectant cell line stained with NKp30 (CLH9), followed by PE-conjugated goat anti-mouse IgG<sub>1</sub>: sc-3764. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-3877. Rat NKp30 transfected 293 cell line kindly provided by Christine Hsieh of Stanford University.

NKp30 (G-19) - sc-20477 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NKp30 (G-19): sc-20477. Western blot analysis of NKp30 expression in THP-1 whole cell lysate.

NKp30 (N-20) - sc-20476 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-NCR3 antibody - ab203390 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed paraffin-embedded Human lung carcinoma tissue, labeling NCR3 using ab203390 at a 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Anti-NCR3 antibody - ab136996 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-NCR3 antibody (ab136996) at 1/500 dilution + K562 cell lysate at 30 µg

Anti-NCR3 antibody [9D31] - ab196527 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 9D31

Anti-NCR3 antibody [EPR14509] - ab186425 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14509
All lanes : Anti-NCR3 antibody [EPR14509] (ab186425) at 1/1000 dilutionLane 1 : THP1 cell lysateLane 2 : NCI-H460 lysateLane 3 : Rat brain lysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution

Anti-NCR3 antibody [y4E6] - ab26250 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone y4E6
Anti-NCR3 antibody [y4E6] (ab26250) at 1/1000 dilution + human recombinant protein NCR3 (residues 19-138) (50ng)Secondarygoat anti-mouse secondary antibody conjugated to HRP

Anti-NKP30 Antibody (clone P30-15) - LS-C40795 from LifeSpan Bioscience

Prices $235.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone P30-15
Human peripheral blood lymphocytes stained with purified P30-15, followed by anti-mouse IgG FITC

Anti-NKP30 Antibody (Extracellular Domain, clone Y4E6) - LS-C93761 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone Y4E6
Human recombinant proteins, extracellular domain of NKp30(50ng) was resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human NKp30 (1:1000). Protein was visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Arrow indicates human recombinant protein NKp30 (residues 19~138).

Anti-NKP30 Antibody (aa104-153) - LS-C120136 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from A549 cells, using NCR3 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-NKP30 Antibody (Leu134) - LS-C177863 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of NKp30 (L134) pAb in extracts from A549 cells.

Anti-NKP30 Antibody (aa85-134) - LS-C200256 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from K562 cells using NCR3 antibody.

Anti-NKP30 Antibody - LS-C334983 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of U2OS cell using NCR3 antibody. Blue: DAPI for nuclear staining.

NKp30/NCR3 Antibody (210845) - MAB1849 from Novus Biologicals

Prices $99.00, $269.00, $699.00
Sizes 25 µg, 100 µg, 500 µg
Host Mouse
Clonality Monoclonal
Clone 210845
Human NKp30 Monoclonal Antibody induces IFN‑ gamma secretion in the NK-92 human natural killer lymphoma cell line in a dose-dependent manner, as measured using the Quantikine Human IFN‑ gamma ELISA Kit (Catalog # DIF50). The ED50 for this effect is typically 0.2‑1.2 μg/mL.

NKp30/NCR3 Antibody - AF1849 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal

NKp30/NCR3 Antibody - NBP1-68581 from Novus Biologicals

Prices $229.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: NCR3 Antibody [NBP1-68581] - Analysis of extracts from A549 cells, using NCR3 Antibody. The lane on the right is treated with the synthesized peptide.

NKp30/NCR3 Antibody - NBP1-51384 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: NCR3 Antibody [NBP1-51384] - Analysis of NKR3 (L134) pAb in extracts from A549 cells.

NKp30/NCR3 Antibody (y4E6) - NBP1-04313 from Novus Biologicals

Prices $309.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone y4E6
Western Blot: NCR3 Antibody (y4E6) [NBP1-04313] - Human recombinant proteins, extracellular domain of NKp30(50ng) was resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human NKp30 (1:1000). Protein was visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Arrow indicates human recombinant protein NKp30 (residues 19~138).

NKp30/NCR3 Antibody (MM0490-9D31) - NBP2-11819 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0490-9D31

NKp30/NCR3 Antibody (210845) [PE] - FAB1849P-100 from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone 210845

NKp30/NCR3 Antibody (210845) [PE] - FAB1849P-025 from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone 210845

NKp30/NCR3 Antibody [Biotin] - BAF1849 from Novus Biologicals

Prices $390.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

NKp30/NCR3 Antibody (210845) [Alexa Fluor (R) 488] - FAB1849G-100 from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone 210845
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