Gene Symbol | SNX10 |
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Entrez Gene | 29887 |
Alt Symbol | OPTB8 |
Species | Human |
Gene Type | protein-coding |
Description | sorting nexin 10 |
Other Description | sorting nexin-10 |
Swissprots | Q8IYT5 E9PFH5 Q9Y5X0 |
Accessions | AAS02029 AAS07476 EAL24234 EAW93848 EAW93849 EAW93850 EAW93851 Q9Y5X0 AF121860 AAD27833 AK296142 BAG58882 AK307905 AK309162 AK311256 AK312850 BAG35703 AK316088 BAH14459 BC031050 AAH31050 BC034992 AAH34992 BG399132 BJ995940 BM147840 BM147978 BX648363 DQ892420 ABM83346 DQ895634 ABM86560 XM_006715710 XP_006715773 XM_006715711 XP_006715774 XM_006715712 XP_006715775 NM_001199835 NP_001186764 NM_001199837 NP_001186766 NM_001199838 NP_001186767 NM_013322 NP_037454 NR_037670 |
Function | Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption. {ECO:0000269|PubMed:17012226, ECO:0000269|PubMed:21844891, ECO:0000269|PubMed:22499339}. |
Subcellular Location | Cytoplasm. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=May also localize to nucleus and endoplasmic reticulum. |
SNX10 CRISPR/Cas9 KO Plasmid (h) - sc-416307 from Santa Cruz Biotechnology
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SNX10 HDR Plasmid (h) - sc-416307-HDR from Santa Cruz Biotechnology
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SNX10 Double Nickase Plasmid (h) - sc-416307-NIC from Santa Cruz Biotechnology
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SNX10 Double Nickase Plasmid (h2) - sc-416307-NIC-2 from Santa Cruz Biotechnology
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SNX10 CRISPR Activation Plasmid (h) - sc-416307-ACT from Santa Cruz Biotechnology
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SNX10 CRISPR Activation Plasmid (h2) - sc-416307-ACT-2 from Santa Cruz Biotechnology
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SNX10 Lentiviral Activation Particles (h) - sc-416307-LAC from Santa Cruz Biotechnology
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SNX10 Lentiviral Activation Particles (h2) - sc-416307-LAC-2 from Santa Cruz Biotechnology
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SNX10 siRNA (h) - sc-89345 from Santa Cruz Biotechnology
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SNX10 shRNA Plasmid (h) - sc-89345-SH from Santa Cruz Biotechnology
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SNX10 shRNA (h) Lentiviral Particles - sc-89345-V from Santa Cruz Biotechnology
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SNX10 RNAi - H00029887-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN20288 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20288 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10322 from Sigma-Aldrich
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SNX10 siRNA (Human) - CRH9248 from Cohesion Biosciences
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SNX10 - MBS8205275 from MyBioSource
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shRNA set against Human SNX10 (NM_013322.2) - SHH414560 from Creative biogene
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shRNA set against Human SNX10(NM_013322.2) - SHL022940 from Creative biogene
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Human SNX10 siRNA - orb269750 from Biorbyt
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SNX10 shRNA Plasmid (Human) - CHH9248 from Cohesion Biosciences
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SNX10 miRNA 3'UTR clone - MiUTR1H-09710 from Creative biogene
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