Gene Symbol | Polr1c |
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Entrez Gene | 20016 |
Alt Symbol | 40kDa, AA409007, AA959927, AL024089, Polr1e, RPA40, Rpo1-1 |
Species | Mouse |
Gene Type | protein-coding |
Description | polymerase (RNA) I polypeptide C |
Other Description | AC40|DNA-directed RNA polymerase I subunit C|DNA-directed RNA polymerases I and III 40 kDa polypeptide|DNA-directed RNA polymerases I and III subunit RPAC1|RNA polymerase 1-1 (40 kDa subunit)|RNA polymerases I and III subunit AC1|RPC40 |
Swissprots | Q3UJZ9 P52432 |
Accessions | EDL23483 EDL23484 P52432 AK132114 BAE20986 AK146240 BAE27005 AK180462 BC130018 AAI30019 BY267923 CJ207889 NM_009085 NP_033111 |
Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000250}. |
Top Pathways | Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism |
RPA40 CRISPR/Cas9 KO Plasmid (m) - sc-422728 from Santa Cruz Biotechnology
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RPA40 HDR Plasmid (m) - sc-422728-HDR from Santa Cruz Biotechnology
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RPA40 Double Nickase Plasmid (m) - sc-422728-NIC from Santa Cruz Biotechnology
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RPA40 Double Nickase Plasmid (m2) - sc-422728-NIC-2 from Santa Cruz Biotechnology
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RPA40 CRISPR Activation Plasmid (m) - sc-422728-ACT from Santa Cruz Biotechnology
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RPA40 CRISPR Activation Plasmid (m2) - sc-422728-ACT-2 from Santa Cruz Biotechnology
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RPA40 Lentiviral Activation Particles (m) - sc-422728-LAC from Santa Cruz Biotechnology
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RPA40 Lentiviral Activation Particles (m2) - sc-422728-LAC-2 from Santa Cruz Biotechnology
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RPA40 siRNA (m) - sc-38243 from Santa Cruz Biotechnology
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RPA40 shRNA Plasmid (m) - sc-38243-SH from Santa Cruz Biotechnology
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RPA40 shRNA (m) Lentiviral Particles - sc-38243-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU073961 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN39031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND39031 from Sigma-Aldrich
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POLR1C siRNA (Mouse) - CRM3530 from Cohesion Biosciences
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shRNA set against Mouse POLR1C (NM_009085.2) - SHH379348 from Creative biogene
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shRNA set against Mouse Rpo1-1(NM_009085.2) - SHR195844 from Creative biogene
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POLR1C shRNA Plasmid (Mouse) - CHM3530 from Cohesion Biosciences
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POLR1C miRNA 3'UTR clone - MiUTR1M-10260 from Creative biogene
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