Gene Symbol | LIPN |
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Entrez Gene | 643418 |
Alt Symbol | ARCI8, LI4, LIPL4, bA186O14.3 |
Species | Human |
Gene Type | protein-coding |
Description | lipase, family member N |
Other Description | lipase member N|lipase-like abhydrolase domain-containing protein 4 |
Swissprots | A7KIH9 Q5VXI9 |
Accessions | Q5VXI9 EF426483 ABR08388 XM_005270049 XP_005270106 XM_011540083 XP_011538385 XM_011540084 XP_011538386 XM_011540085 XP_011538387 XM_011540086 XP_011538388 XR_945801 NM_001102469 NP_001095939 |
Function | Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers. {ECO:0000269|PubMed:17562024}. |
Subcellular Location | Secreted {ECO:0000305}. |
Tissue Specificity | Highly expressed in the epidermis in the granular keratinocytes. Also detected in other tissues, although at much lower levels, including lung and spleen. {ECO:0000269|PubMed:17562024, ECO:0000269|PubMed:21439540}. |
LIPN CRISPR/Cas9 KO Plasmid (h) - sc-416112 from Santa Cruz Biotechnology
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LIPN HDR Plasmid (h) - sc-416112-HDR from Santa Cruz Biotechnology
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LIPN Double Nickase Plasmid (h) - sc-416112-NIC from Santa Cruz Biotechnology
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LIPN Double Nickase Plasmid (h2) - sc-416112-NIC-2 from Santa Cruz Biotechnology
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LIPN CRISPR Activation Plasmid (h) - sc-416112-ACT from Santa Cruz Biotechnology
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LIPN CRISPR Activation Plasmid (h2) - sc-416112-ACT-2 from Santa Cruz Biotechnology
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LIPN Lentiviral Activation Particles (h) - sc-416112-LAC from Santa Cruz Biotechnology
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LIPN Lentiviral Activation Particles (h2) - sc-416112-LAC-2 from Santa Cruz Biotechnology
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LIPN siRNA (h) - sc-90336 from Santa Cruz Biotechnology
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LIPN shRNA Plasmid (h) - sc-90336-SH from Santa Cruz Biotechnology
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LIPN shRNA (h) Lentiviral Particles - sc-90336-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU104161 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11750 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11750 from Sigma-Aldrich
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LIPN siRNA (Human) - CRJ8457 from Cohesion Biosciences
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LIPN shRNA Plasmid (Human) - CHJ8457 from Cohesion Biosciences
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