Gene Symbol | Cdkn2b |
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Entrez Gene | 12579 |
Alt Symbol | AV083695, INK4b, MTS2, p15, p15(INK4b), p15INK4b |
Species | Mouse |
Gene Type | protein-coding |
Description | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) |
Other Description | cyclin-dependent kinase 4 inhibitor B|cyclin-dependent kinase inhibitor p15|cyclin-dependent kinase inhibitor p15INK4b|cyclin-dependent kinase inhibitor protein|p14-INK4b|p15-INK4b |
Swissprots | P55271 |
Accessions | AAB39833 AAB94534 AAD00232 AAD00233 AAD00234 AAD00356 AAD00357 AAD00358 EDL30950 P55271 AF059567 AAC14569 AK144132 BAE25719 AK146668 BC002010 AAH02010 DT919921 NM_007670 NP_031696 |
Function | Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest (By similarity). {ECO:0000250}. |
Tissue Specificity | Expressed ubiquitously. |
Top Pathways | Cell cycle, TGF-beta signaling pathway, Small cell lung cancer, HTLV-I infection, Viral carcinogenesis |
p15 CRISPR/Cas9 KO Plasmid (m) - sc-419611 from Santa Cruz Biotechnology
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p15 HDR Plasmid (m) - sc-419611-HDR from Santa Cruz Biotechnology
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p15 Double Nickase Plasmid (m) - sc-419611-NIC from Santa Cruz Biotechnology
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p15 Double Nickase Plasmid (m2) - sc-419611-NIC-2 from Santa Cruz Biotechnology
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p15 CRISPR Activation Plasmid (m) - sc-419611-ACT from Santa Cruz Biotechnology
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p15 CRISPR Activation Plasmid (m2) - sc-419611-ACT-2 from Santa Cruz Biotechnology
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p15 Lentiviral Activation Particles (m) - sc-419611-LAC from Santa Cruz Biotechnology
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p15 Lentiviral Activation Particles (m2) - sc-419611-LAC-2 from Santa Cruz Biotechnology
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p15 siRNA (m) - sc-37625 from Santa Cruz Biotechnology
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p15 shRNA Plasmid (m) - sc-37625-SH from Santa Cruz Biotechnology
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p15 shRNA (m) Lentiviral Particles - sc-37625-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN28510 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND28510 from Sigma-Aldrich
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CDKN2B siRNA (Mouse) - CRM0651 from Cohesion Biosciences
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CDKN2B - MBS8233920 from MyBioSource
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shRNA set against Mouse CDKN2B (NM_007670.4) - SHH260885 from Creative biogene
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Mouse CDKN2B siRNA - orb280127 from Biorbyt
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CDKN2B shRNA Plasmid (Mouse) - CHM0651 from Cohesion Biosciences
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