| Gene Symbol |
a
|
| Entrez Gene |
50518
|
| Alt Symbol |
A<y>, ASIP, ASP, As
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
nonagouti
|
| Other Description |
agouti coat color protein|agouti signal protein|agouti switch protein|agouti-signaling protein|non-agouti
|
| Swissprots |
A2ALT3 Q03288 Q80ST0
|
| Accessions |
EDL06104 EDL06105 EDL06106 Q03288 AK156952 AK172452 BC009122 L06451 AAA37201 L06452 L06941 S63413 AAA15908 S70320 AAP19635 S70326 AAP19636 S70394 AAP19637 S74479 AAP31517 S74489 AAP31519 S74493 AAP31520 XM_011239689 XP_011237991 XM_011239690 XP_011237992 XM_011239691 XP_011237993 XM_011251809 XP_011250111 XM_011251810 XP_011250112 XR_375144 XR_375145 XR_375146 XR_375149 XR_400376 XR_400377 XR_400378 XR_400381 XR_866315 XR_866316 XR_866317 XR_866319 XR_866320 XR_866321 XR_866322 XR_886317 XR_886318 XR_886319 XR_886320 XR_886321 XR_886322 XR_886323 NM_015770 NP_056585
|
| Function |
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). Causes hair follicle melanocytes to synthesize phaeomelanin instead of black or brown pigment eumelanin and produces hairs with a subapical yellow band on an otherwise black or brown background when expressed during the mid-portion of hair growth.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Epithelial cells of the hair follicles and the epidermis.
|
| Top Pathways |
Melanogenesis
|
