| Gene Symbol |
CC2D1A
|
| Entrez Gene |
54862
|
| Alt Symbol |
FREUD-1, Freud-1/Aki1, MRT3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
coiled-coil and C2 domain containing 1A
|
| Other Description |
Akt kinase-interacting protein 1|FRE under dual repression-binding protein 1|coiled-coil and C2 domain-containing protein 1A|five prime repressor element under dual repression-binding protein 1|five repressor element under dual repression-binding protein 1|mental retardation, nonsyndromic, autosomal recessive, 3|putative NF-kappa-B-activating protein 023N|putative NFkB activating protein
|
| Swissprots |
Q9NXI1 Q9H603 Q8NF89 Q86XV0 Q7Z435 Q6P1N0
|
| Accessions |
EAW84380 Q6P1N0 AB097002 BAC77355 AF536205 AAN04488 AK000248 BAA91029 AK023399 BAB14561 AK026371 BAB15464 AK123155 AK315068 BC006556 BC048345 AAH48345 BC064981 AAH64981 BC113968 AAI13969 BP395853 DB065701 XM_005259972 XP_005260029 XM_005259973 XP_005260030 XM_005259974 XP_005260031 XM_005259975 XP_005260032 NM_017721 NP_060191
|
| Function |
Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. {ECO:0000250, ECO:0000269|PubMed:20171170}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
|
