| Gene Symbol |
EAPP
|
| Entrez Gene |
55837
|
| Alt Symbol |
BM036, C14orf11
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
E2F-associated phosphoprotein
|
| Other Description |
-
|
| Swissprots |
Q9BVF4 Q9NZ86 Q56P03 Q9NWV5
|
| Accessions |
CCQ43598 EAW65920 EAW65921 EAW65922 Q56P03 AF217512 AAF67623 AK000585 BAA91271 AK225467 AK225477 AK225991 AY157300 AAO17041 AY157301 AAO17042 AY869694 AAX63200 BC001245 AAH01245 CD702290 HQ447367 ADQ31853 XM_011536958 XP_011535260 XM_011536959 XP_011535261 NM_018453 NP_060923
|
| Function |
May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression. {ECO:0000269|PubMed:15716352}.
|
| Subcellular Location |
Cytoplasm. Nucleus.
|
| Tissue Specificity |
Ubiquitously expressed. Highest levels in heart, placenta, skeletal muscle and pancreas. Lower levels in brain, lung and kidney. In the brain, expressed in all regions with high levels in the cerebellum and cerebral cortex. Expressed in COS1 and transformed skin fibroblasts. {ECO:0000269|PubMed:15716352, ECO:0000269|PubMed:15820313}.
|
![Western Blot: EAPP Overexpression Lysate (Adult Normal) [NBL1-10089] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for EAPP.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2596_EAPP%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10089-img0002.jpg)