FERMT1

Gene Symbol	FERMT1
Entrez Gene	55612
Alt Symbol	C20orf42, DTGCU2, KIND1, UNC112A, URP1
Species	Human
Gene Type	protein-coding
Description	fermitin family member 1
Other Description	UNC112 related protein 1|fermitin family homolog 1|kindlerin|kindlin 1|kindlin syndrome protein|unc-112-related protein 1
Swissprots	D3DW10 Q8IX34 Q9BQL6 Q8IYH2 Q9NXQ3 Q9NWM2
Accessions	EAX10392 EAX10393 EAX10394 EAX10395 Q9BQL6 AB105105 BAD12269 AF443278 AAN75822 AK000123 BAA90957 AK000747 BAA91358 AK025365 AK027076 AK092195 BAC03826 AK225216 AK314394 BAG37018 AY137240 AAM94174 BC035882 AAH35882 BC040545 AAH40545 BX647465 NM_017671 NP_060141
Function	Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression. {ECO:0000269|PubMed:14634021, ECO:0000269|PubMed:17012746, ECO:0000269|PubMed:19804783}.
Subcellular Location	Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Constituent of focal adhesions. Localized at the basal aspect of skin keratinocytes, close to the cell membrane. Colocalizes with filamentous actin. Upon TGFB1 treatment, it localizes to membrane ruffles.
Tissue Specificity	Expressed in brain, skeletal muscle, kidney, colon, adrenal gland, prostate, and placenta. Weakly or not expressed in heart, thymus, spleen, liver, small intestine, bone marrow, lung and peripheral blood leukocytes. Overexpressed in some colon and lung tumors. In skin, it is localized within the epidermis and particularly in basal keratocytes. Not detected in epidermal melanocytes and dermal fibroblasts. {ECO:0000269|PubMed:12668616, ECO:0000269|PubMed:12697302, ECO:0000269|PubMed:12789646, ECO:0000269|PubMed:14634021, ECO:0000269|PubMed:17012746}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Kindlin full length protein - ab132290 from Abcam Category Protein Source Wheat germ Species Human

Human Kindlin peptide - ab69694 from Abcam Category Peptide

Human Kindlin protein fragment - ab153403 from Abcam Category Protein Source Wheat germ Species Human

FERMT1 / Kindlin Antibody Blocking Peptide - LS-E15644 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FERMT1 / Kindlin Antibody Blocking Peptide - LS-E9849 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FERMT1 / Kindlin Antibody Blocking Peptide - LS-E24556 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Kindlin Protein - H00055612-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Kindlin Protein - H00055612-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

FERMT1-Antibody-Center-Blocking-Peptide - BP8912c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FERMT1 Blocking Peptide - 33R-5456 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FERMT1 - H00055612-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

FERMT1 - H00055612-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

FERMT1 - H00055612-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

FERMT1 - H00055612-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

FERMT1 fusion protein - ag17543 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

FERMT1 fusion protein - Ag17672 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human Fermitin family homolog 1(FERMT1) - CSB-YP874786HU CSB-EP874786HU CSB-BP874786HU CSB-MP874786HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Pongo abelii Fermitin family homolog 1(FERMT1) ,partial - CSB-YP732681PYX CSB-EP732681PYX CSB-BP732681PYX CSB-MP732681PYX from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Orangutan

FERMT1 - TP317593 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Kindlin Recombinant Protein Antigen - NBP1-89884PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Kindlin Recombinant Protein Antigen - NBP1-89883PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

FERMT1 Peptide, Human - M34GP05674H from Creative Peptides Category Peptide Source Synthetic. Species Human

Fermitin family homolog 1 (FERMT1), Recombinant Protein - MBS1448797 from MyBioSource Category Protein Prices $1,480.00, $1,480.00, $1,710.00, $1,710.00, $2,525.00, $2,525.00, $2,965.00, $2,965.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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