FERMT1

Gene Symbol	FERMT1
Entrez Gene	55612
Alt Symbol	C20orf42, DTGCU2, KIND1, UNC112A, URP1
Species	Human
Gene Type	protein-coding
Description	fermitin family member 1
Other Description	UNC112 related protein 1|fermitin family homolog 1|kindlerin|kindlin 1|kindlin syndrome protein|unc-112-related protein 1
Swissprots	D3DW10 Q8IX34 Q9BQL6 Q8IYH2 Q9NXQ3 Q9NWM2
Accessions	EAX10392 EAX10393 EAX10394 EAX10395 Q9BQL6 AB105105 BAD12269 AF443278 AAN75822 AK000123 BAA90957 AK000747 BAA91358 AK025365 AK027076 AK092195 BAC03826 AK225216 AK314394 BAG37018 AY137240 AAM94174 BC035882 AAH35882 BC040545 AAH40545 BX647465 NM_017671 NP_060141
Function	Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression. {ECO:0000269|PubMed:14634021, ECO:0000269|PubMed:17012746, ECO:0000269|PubMed:19804783}.
Subcellular Location	Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Constituent of focal adhesions. Localized at the basal aspect of skin keratinocytes, close to the cell membrane. Colocalizes with filamentous actin. Upon TGFB1 treatment, it localizes to membrane ruffles.
Tissue Specificity	Expressed in brain, skeletal muscle, kidney, colon, adrenal gland, prostate, and placenta. Weakly or not expressed in heart, thymus, spleen, liver, small intestine, bone marrow, lung and peripheral blood leukocytes. Overexpressed in some colon and lung tumors. In skin, it is localized within the epidermis and particularly in basal keratocytes. Not detected in epidermal melanocytes and dermal fibroblasts. {ECO:0000269|PubMed:12668616, ECO:0000269|PubMed:12697302, ECO:0000269|PubMed:12789646, ECO:0000269|PubMed:14634021, ECO:0000269|PubMed:17012746}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Anti-FERMT1 / Kindlin Antibody (aa268-297) IHC-plus™ - LS-B9898 from LifeSpan Bioscience Prices $395.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FERMT1 / Kindlin Antibody - LS-C124764 from LifeSpan Bioscience Prices $485.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-FERMT1 / Kindlin Antibody (APC) - LS-C226631 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FERMT1 / Kindlin Antibody (AP) - LS-C226632 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FERMT1 / Kindlin Antibody (Biotin) - LS-C226633 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FERMT1 / Kindlin Antibody (PE) - LS-C226636 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FERMT1 / Kindlin Antibody (Azide-free, HRP) - LS-C226635 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FERMT1 / Kindlin Antibody (FITC) - LS-C226634 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FERMT1 / Kindlin Antibody - LS-C307519 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-FERMT1 / Kindlin Antibody (aa180-270) - LS-C307521 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-FERMT1 / Kindlin Antibody - LS-C310354 from LifeSpan Bioscience Prices $475.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-FERMT1 / Kindlin Antibody (Internal, Azide-free) - LS-C329036 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FERMT1 / Kindlin Antibody (C-Terminus) - LS-C186870 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-FERMT1 / Kindlin Antibody (N-Terminus) - LS-C80511 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-FERMT1 / Kindlin Antibody - LS-C310356 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-FERMT1 / Kindlin Antibody (aa643-660) - LS-C2928 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-FERMT1 / Kindlin Antibody (C-Terminus) - LS-C201422 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-FERMT1 / Kindlin Antibody (aa643-660) IHC-plus™ - LS-B2876 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Kindlin Antibody - NBP1-54990 from Novus Biologicals Prices $369.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Kindlin Antibody - NB100-523 from Novus Biologicals Prices $229.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Kindlin Antibody - NBP1-89883 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Kindlin Antibody - H00055612-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Kindlin Antibody - NBP1-89884 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Kindlin Antibody (1D11) - H00055612-M02 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1D11

Kindlin Antibody - H00055612-D01P from Novus Biologicals Prices $399.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Search more