| Gene Symbol |
PHF19
|
| Entrez Gene |
26147
|
| Alt Symbol |
MTF2L1, PCL3, TDRD19B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
PHD finger protein 19
|
| Other Description |
polycomb like 3|polycomb-like protein 3|tudor domain containing 19B
|
| Swissprots |
Q8TBL6 Q5T6S4 Q32NF2 Q5T6S3 Q6N038 Q9UFS9
|
| Accessions |
EAW87475 EAW87476 EAW87477 EAW87478 Q5T6S3 AA743545 AI193743 AI369987 AK122744 BAG53700 AK302996 BAH13873 AK303433 BAH13959 AL117477 CAB55950 BC022374 AAH22374 BC044224 BC108663 AAI08664 BC125076 AAI25077 BC125077 AAI25078 BM784783 BM784790 BU632411 BX640713 CAE45832 HQ447719 ADQ32204 HY013521 XM_005251906 XP_005251963 XM_006717046 XP_006717109 XM_011518509 XP_011516811 XM_011518510 XP_011516812 XM_011518511 XP_011516813 XM_011518512 XP_011516814 XM_011518513 XP_011516815 XM_011518514 XP_011516816 XM_011518515 XP_011516817 XM_011518516 XP_011516818 XM_011518517 XP_011516819 XR_929758 XR_929759 NM_001009936 NP_001009936 NM_001286840 NP_001273769 NM_001286842 NP_001273771 NM_001286843 NP_001273772 NM_015651 NP_056466 NR_104601
|
| Function |
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases NO66 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds dimethylated at 'Lys- 36' (H3K36me2). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter. {ECO:0000269|PubMed:15563832, ECO:0000269|PubMed:21143197, ECO:0000269|PubMed:23104054, ECO:0000269|PubMed:23160351}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15563832}.
|
| Tissue Specificity |
Isoform 1 is expressed in thymus, heart, lung and kidney. Isoform 2 is predominantly expressed in placenta, skeletal muscle and kidney, whereas isoform 1 is predominantly expressed in liver and peripheral blood leukocytes. Overexpressed in many types of cancers, including colon, skin, lung, rectal, cervical, uterus, liver cancers, in cell lines derived from different stages of melanoma and in glioma cell lines. {ECO:0000269|PubMed:15563832}.
|