Gene Symbol | Htr1f |
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Entrez Gene | 15557 |
Alt Symbol | Htr1eb |
Species | Mouse |
Gene Type | protein-coding |
Description | 5-hydroxytryptamine (serotonin) receptor 1F |
Other Description | 5-HT-1E-beta|5-HT-1F|5-HT1F|5-hydroxytryptamine (serotonin) receptor 1E beta|5-hydroxytryptamine receptor 1F|serotonin receptor 1F |
Swissprots | Q02284 |
Accessions | EDK98243 Q02284 AK045364 BAC32328 BC120507 AAI20508 BC137604 AAI37605 Z14224 CAA78593 XM_011245833 XP_011244135 NM_008310 NP_032336 |
Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. {ECO:0000269|PubMed:1328180}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:1328180}; Multi-pass membrane protein {ECO:0000269|PubMed:1328180}. |
Tissue Specificity | Detected in hippocampus. {ECO:0000269|PubMed:1328180}. |
Top Pathways | cAMP signaling pathway, Neuroactive ligand-receptor interaction |
SR-1F CRISPR/Cas9 KO Plasmid (m) - sc-420992 from Santa Cruz Biotechnology
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SR-1F HDR Plasmid (m) - sc-420992-HDR from Santa Cruz Biotechnology
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SR-1F Double Nickase Plasmid (m) - sc-420992-NIC from Santa Cruz Biotechnology
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SR-1F Double Nickase Plasmid (m2) - sc-420992-NIC-2 from Santa Cruz Biotechnology
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SR-1F CRISPR Activation Plasmid (m) - sc-420992-ACT from Santa Cruz Biotechnology
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SR-1F CRISPR Activation Plasmid (m2) - sc-420992-ACT-2 from Santa Cruz Biotechnology
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SR-1F Lentiviral Activation Particles (m) - sc-420992-LAC from Santa Cruz Biotechnology
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SR-1F Lentiviral Activation Particles (m2) - sc-420992-LAC-2 from Santa Cruz Biotechnology
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SR-1F siRNA (m) - sc-42230 from Santa Cruz Biotechnology
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SR-1F shRNA Plasmid (m) - sc-42230-SH from Santa Cruz Biotechnology
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SR-1F shRNA (m) Lentiviral Particles - sc-42230-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU023931 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN33547 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33547 from Sigma-Aldrich
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HTR1F siRNA (Mouse) - CRM1961 from Cohesion Biosciences
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HTR1F - MBS8204483 from MyBioSource
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shRNA set against Mouse HTR1F (NM_008310.3) - SHH315905 from Creative biogene
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shRNA set against Mouse Htr1f(NM_008310.3) - SHH135569 from Creative biogene
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HTR1F shRNA Plasmid (Mouse) - CHM1961 from Cohesion Biosciences
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HTR1F miRNA 3'UTR clone - MiUTR1M-05845 from Creative biogene
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