| Gene Symbol |
Rad54l
|
| Entrez Gene |
19366
|
| Alt Symbol |
RAD54
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
RAD54 like (S. cerevisiae)
|
| Other Description |
DNA repair and recombination protein RAD54-like|RAD54 homolog|mHR54|mRAD54
|
| Swissprots |
Q8BSR5 P70270 Q8C2C4 Q8K3D4
|
| Accessions |
EDL30621 P70270 AK017045 AK030753 AK088876 BAC40627 AK161644 AK185368 AK186969 AK187004 AK210074 AK216916 AK217837 BC021643 AAH21643 BY716729 CN669448 X97796 CAA66380 XM_006502877 XP_006502940 XM_006502878 XP_006502941 XM_006502879 XP_006502942 XM_006502880 XP_006502943 XR_867829 NM_001122958 NP_001116430 NM_001122959 NP_001116431 NM_009015 NP_033041
|
| Function |
Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52) pathway. Dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Could be involved in the turnover of RAD51 protein-dsDNA filaments (By similarity). Deficient mice also show significantly shorter telomeres than wild-type controls, indicating that the protein activity plays an essential role in telomere length maintenance in mammals. Deficiency also resulted in an increased frequency of end-to-end chromosome fusions involving telomeres compared to the controls, suggesting a putative role in telomere capping. Non- homologous end joining (NHEJ) and homologous recombination (HR) represent the two major pathways of DNA double-strand break (DSB) repair in eukaryotic cells. LIG4 and RAD54L cooperate to support cellular proliferation, repair spontaneous DSBs, and prevent chromosome and single chromatid aberrations. {ECO:0000250, ECO:0000269|PubMed:10209103, ECO:0000269|PubMed:10757799,
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Hardly detectable in most tissues. Dramatically increased in thymus, spleen and testis. {ECO:0000269|PubMed:8805304}.
|
| Top Pathways |
Homologous recombination
|