Rad54l

Gene Symbol Rad54l
Entrez Gene 19366
Alt Symbol RAD54
Species Mouse
Gene Type protein-coding
Description RAD54 like (S. cerevisiae)
Other Description DNA repair and recombination protein RAD54-like|RAD54 homolog|mHR54|mRAD54
Swissprots Q8BSR5 P70270 Q8C2C4 Q8K3D4
Accessions EDL30621 P70270 AK017045 AK030753 AK088876 BAC40627 AK161644 AK185368 AK186969 AK187004 AK210074 AK216916 AK217837 BC021643 AAH21643 BY716729 CN669448 X97796 CAA66380 XM_006502877 XP_006502940 XM_006502878 XP_006502941 XM_006502879 XP_006502942 XM_006502880 XP_006502943 XR_867829 NM_001122958 NP_001116430 NM_001122959 NP_001116431 NM_009015 NP_033041
Function Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52) pathway. Dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Could be involved in the turnover of RAD51 protein-dsDNA filaments (By similarity). Deficient mice also show significantly shorter telomeres than wild-type controls, indicating that the protein activity plays an essential role in telomere length maintenance in mammals. Deficiency also resulted in an increased frequency of end-to-end chromosome fusions involving telomeres compared to the controls, suggesting a putative role in telomere capping. Non- homologous end joining (NHEJ) and homologous recombination (HR) represent the two major pathways of DNA double-strand break (DSB) repair in eukaryotic cells. LIG4 and RAD54L cooperate to support cellular proliferation, repair spontaneous DSBs, and prevent chromosome and single chromatid aberrations. {ECO:0000250, ECO:0000269|PubMed:10209103, ECO:0000269|PubMed:10757799,
Subcellular Location Nucleus {ECO:0000305}.
Tissue Specificity Hardly detectable in most tissues. Dramatically increased in thymus, spleen and testis. {ECO:0000269|PubMed:8805304}.
Top Pathways Homologous recombination

Rad54 CRISPR/Cas9 KO Plasmid (m) - sc-422584 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Rad54 HDR Plasmid (m) - sc-422584-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Rad54 Double Nickase Plasmid (m) - sc-422584-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Rad54 Double Nickase Plasmid (m2) - sc-422584-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Rad54 CRISPR Activation Plasmid (m) - sc-422584-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Rad54 CRISPR Activation Plasmid (m2) - sc-422584-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Rad54 Lentiviral Activation Particles (m) - sc-422584-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Rad54 Lentiviral Activation Particles (m2) - sc-422584-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Rad54 siRNA (m) - sc-36363 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Rad54 shRNA Plasmid (m) - sc-36363-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Rad54 shRNA (m) Lentiviral Particles - sc-36363-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU049381 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN39838 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND39838 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

RAD54L siRNA (Mouse) - CRM3394 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

RAD54L - MBS8239223 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse Rad54l (NM_009015.3) - SHH389092 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse RAD54L siRNA - orb282870 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

RAD54L shRNA Plasmid (Mouse) - CHM3394 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse
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