ATAD5
| Gene Symbol | ATAD5 |
|---|---|
| Entrez Gene | 79915 |
| Alt Symbol | C17orf41, ELG1, FRAG1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATPase family, AAA domain containing 5 |
| Other Description | ATPase family AAA domain-containing protein 5|chromosome fragility associated gene 1|chromosome fragility-associated gene 1 protein|enhanced level of genomic instability 1 homolog |
| Swissprots | Q9H9I1 Q96QE3 Q05DH0 Q69YR6 |
| Accessions | Q96QE3 AJ314648 CAC44537 AK022797 BAB14248 AL832103 CAH10412 AY557611 AAT52049 BC015051 AAH15051 BC148343 AAI48344 DB527289 DR159473 XM_011525269 XP_011523571 XM_011525270 XP_011523572 XM_011525271 XP_011523573 XM_011525272 XP_011523574 XM_011525273 XP_011523575 XM_011525274 XP_011523576 XR_934553 NM_024857 NP_079133 |
| Function | Involved in DNA damage response. Involved in a RAD9A- related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages- induced apoptosis. {ECO:0000269|PubMed:15983387}. |
| Subcellular Location | Nucleus {ECO:0000305}. |
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![Anti-Elg1 Antibody - Western Blot. Western blot of Affinity Purified anti-Elg1 antibody shows detection of a band ~120 kD corresponding to human Elg1 (arrowhead) in various cell lysates. Lanes contain ~5 ug of HeLa nuclear extract (1), HeLa (2), A431 (3), Jurkat (4) and HEK293 (5) whole cell lysates. After SDS-PAGE, transfer and blocking, the membrane was probed with the primary antibody diluted to 1:500. The membrane was then washed and reacted with a HRP conjugated Gt-a-Rabbit IgG [H&L] MX followed by ECL detection using a 2 m exposure time. The expected molecular weight of Elg1 is 120kD according to Kanellis P et al. 2003, although the predicted molecular weight is 207 kD. The 50kD bands in Jurkat and 293 cell lysates are probably cross-reaction with other proteins. Both the 120 kD and 50 kD bands are not observed when antibody is pre-incubated with peptide (data not shown).](http://www.bioprodhub.com/system/product_images/ab_products/3/sub_1/10279_62871_184051.jpg)
![Western Blot: Atad5 Antibody [NB100-57495] - Detection of Human ATAD5/FRAG1 on HeLa whole cell lysates using NB100-57495.](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_3/4168_Atad5%2520Antibody-Western%2520Blot-NB100-57495-img0001.jpg)
