| Gene Symbol |
Chil3
|
| Entrez Gene |
12655
|
| Alt Symbol |
AI505981, Chi3l3, ECF-L, Ym1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
chitinase-like 3
|
| Other Description |
beta-N-acetylhexosaminidase Ym1|chitinase 3-like 3|chitinase-3-like protein 3|chitinase-like protein 3|eosinophil chemotactic cytokine|eosinophil chemotactic factor-L|secreted protein Ym1
|
| Swissprots |
P70201 Q3UV87 Q3U462 Q61201 O35744
|
| Accessions |
AAN04032 O35744 AK137503 BAE23385 AK154420 BAE32572 BC061154 AAH61154 BY117835 D87757 BAA13458 M94584 AAB62394 U56900 AAB01230 NM_009892 NP_034022
|
| Function |
Lectin that binds saccharides with a free amino group, such as glucosamine or galactosamine. Binding to oligomeric saccharides is much stronger than binding to mono- or disaccharides. Also binds chitin and heparin. Has weak hexosaminidase activity but no chitinase activity. Has chemotactic activity for T-lymphocytes, bone marrow cells and eosinophils. May play a role in inflammation and allergy. {ECO:0000269|PubMed:10625674, ECO:0000269|PubMed:11297523, ECO:0000269|PubMed:11733538}.
|
| Subcellular Location |
Secreted. Rough endoplasmic reticulum lumen. Nucleus envelope. Cytoplasm. Cytoplasmic granule. Note=Predominantly localizes to the lumen of rough endoplasmic reticulum (rER) and nuclear envelope in alveolar macrophages. Localizes to the dilated lumen of rER in immature neutrophils in spleen and in cytoplasmic granules in peritoneal neutrophils. Detected in needle-shaped crystals present in the cytoplasm of bone marrow macrophages.
|
| Tissue Specificity |
Expressed in peritoneal cavity macrophages and in peritoneal and bone marrow-derived neutrophils. Abundantly expressed in bone marrow, with moderate levels detected in gastric antrum, spleen and in alveolar macrophages in lung. Not detected in brain, heart, liver, kidney, stomach, intestine, skeletal muscle, ovary, testis, thymus and lymph nodes (at protein level). Detected at low levels in bone marrow, spleen, thymus and lung. Barely detectable in intestine, kidney and coecum. {ECO:0000269|PubMed:10625674, ECO:0000269|PubMed:11297523, ECO:0000269|PubMed:11733538, ECO:0000269|PubMed:12101265, ECO:0000269|PubMed:15148607, ECO:0000269|PubMed:9828134}.
|