FYB

Gene Symbol FYB
Entrez Gene 2533
Alt Symbol ADAP, PRO0823, SLAP-130, SLAP130
Species Human
Gene Type protein-coding
Description FYN binding protein
Other Description FYB-120/130|FYN-T-binding protein|FYN-binding protein|SLP-76-associated phosphoprotein|adhesion and degranulation-promoting adaptor protein|p120/p130
Swissprots E9PBV9 B4DLN2 O00359 A8K2Y8 O15117 Q9NZI9
Accessions EAW55981 EAW55982 EAW55983 EAW55984 EAW55985 O15117 AF001862 AAB62226 AF116653 AAF71073 AF198052 AAF62400 AI961953 AK123918 AK130159 AK290403 BAF83092 AK297077 BAG59594 AV761195 BC015933 AAH15933 BC017775 BC058827 BC117449 AAI17450 BC143645 AAI43646 BP265190 BQ015514 BX647195 BX647196 CD691549 CD701507 U93049 AAC51300 XM_006714464 XP_006714527 XM_006714465 XP_006714528 XM_006714466 XP_006714529 XM_011514008 XP_011512310 XM_011514009 XP_011512311 XM_011514010 XP_011512312 XM_011514011 XP_011512313 XM_011514012 XP_011512314 XM_011514013 XP_011512315 NM_001243093 NP_001230022 NM_001465 NP_001456 NM_199335 NP_955367
Function Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton. {ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:9671755}. Nucleus {ECO:0000250}.
Tissue Specificity Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues.
Top Pathways Rap1 signaling pathway

ADAP Antibody - 11957 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from NK-92, MOLT-4, and Raw 264.7 cells using ADAP Antibody.

Fyb (H-3) - sc-393276 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fyb (H-3): sc-393276. Western blot analysis of Fyb expression in Jurkat (A), MEG-01 (B), A-549 (C), Raji (D) and TH-1 (E) whole cell lysates.

Fyb (C-20) - sc-7105 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Fyb (H-111) - sc-366689 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Fyb (H-111): sc-366689. Western blot analysis of Fyb expression in Jurkat whole cell lysate.

Fyb (N-18) - sc-7106 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Fyb (N-18): sc-7106. Western blot analysis of Fyb expression in Jurkat whole cell lysate.

Fyb (5) - sc-135913 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Fyb (5): sc-135913. Western blot analysis of Fyb expression in Jurkat whole cell lysate.

Anti-FYB antibody - ab169837 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal

Anti-FYB antibody - ab111611 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-FYB antibody (ab111611) at 1/1000 dilution + Raji whole cell lysate at 30 µg

Anti-FYB antibody - ab125455 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-FYB antibody (ab125455) at 1 µg/ml + A549 cell lysate at 10 µgSecondaryGoat anti-Rabbit IgG-HRP

Anti-FYB antibody [EP2546Y] - ab76103 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP2546Y
Anti-FYB antibody [EP2546Y] (ab76103) at 1/10000 dilution + TF-1 lysate at 10 µgSecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-FYB antibody [EPR2547Y] - ab76006 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2547Y
Anti-FYB antibody [EPR2547Y] (ab76006) at 1/500 dilution + TF-1 lysate at 10 µgSecondaryGoat anti-rabbit HRP at 1/1000 dilution

Anti-FYB antibody [MM0908-31W50] - ab201667 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0908-31W50

Anti-FYB antibody - C-terminal - ab170673 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-FYB antibody - C-terminal (ab170673) at 1/100 dilution + MDA-MB435 cell lysate at 35 µg

Anti-ADAP / FYB Antibody - LS-C34874 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-ADAP / FYB Antibody - LS-C63656 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-ADAP / FYB Antibody (aa755-768) - LS-C3555 from LifeSpan Bioscience

Prices $530.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-ADAP / FYB Antibody (aa2-274) - LS-C63657 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-ADAP / FYB Antibody (aa646-675, AP) - LS-C257464 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ADAP / FYB Antibody (aa646-675, APC) - LS-C257465 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ADAP / FYB Antibody (aa646-675, Biotin) - LS-C257466 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ADAP / FYB Antibody (aa646-675, Azide-free, HRP) - LS-C257468 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ADAP / FYB Antibody (aa646-675, PE) - LS-C257469 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ADAP / FYB Antibody (aa39-88) - LS-C146173 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FYB antibody LS-C146173 Western blot of 293T Cell lysate. Antibody concentration 1 ug/ml.

Anti-ADAP / FYB Antibody (aa646-695) - LS-C146374 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FYB antibody LS-C146374 Western blot of A549 Cell lysate. Antibody concentration 1 ug/ml.

Anti-ADAP / FYB Antibody (aa645-675) - LS-C321495 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Search more