| Gene Symbol |
FYB
|
| Entrez Gene |
2533
|
| Alt Symbol |
ADAP, PRO0823, SLAP-130, SLAP130
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
FYN binding protein
|
| Other Description |
FYB-120/130|FYN-T-binding protein|FYN-binding protein|SLP-76-associated phosphoprotein|adhesion and degranulation-promoting adaptor protein|p120/p130
|
| Swissprots |
E9PBV9 B4DLN2 O00359 A8K2Y8 O15117 Q9NZI9
|
| Accessions |
EAW55981 EAW55982 EAW55983 EAW55984 EAW55985 O15117 AF001862 AAB62226 AF116653 AAF71073 AF198052 AAF62400 AI961953 AK123918 AK130159 AK290403 BAF83092 AK297077 BAG59594 AV761195 BC015933 AAH15933 BC017775 BC058827 BC117449 AAI17450 BC143645 AAI43646 BP265190 BQ015514 BX647195 BX647196 CD691549 CD701507 U93049 AAC51300 XM_006714464 XP_006714527 XM_006714465 XP_006714528 XM_006714466 XP_006714529 XM_011514008 XP_011512310 XM_011514009 XP_011512311 XM_011514010 XP_011512312 XM_011514011 XP_011512313 XM_011514012 XP_011512314 XM_011514013 XP_011512315 NM_001243093 NP_001230022 NM_001465 NP_001456 NM_199335 NP_955367
|
| Function |
Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton. {ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:9671755}. Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues.
|
| Top Pathways |
Rap1 signaling pathway
|
![Western Blot: FYB Overexpression Lysate (Adult Normal) [NBP2-08205] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FYB.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/14579_FYB%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-08205-img0001.jpg)