| Gene Symbol | GRM1 |
|---|---|
| Entrez Gene | 2911 |
| Alt Symbol | GPRC1A, MGLU1, MGLUR1, PPP1R85, SCAR13 |
| Species | Human |
| Gene Type | protein-coding |
| Description | glutamate receptor, metabotropic 1 |
| Other Description | metabotropic glutamate receptor 1|protein phosphatase 1, regulatory subunit 85 |
| Swissprots | Q13255 F8W805 Q5VTF8 Q5VTF7 Q13256 Q9UGT0 Q9NU10 Q9UGS9 B9EG79 Q14757 Q14758 |
| Accessions | EAW47834 EAW47835 Q13255 AB208837 BAD92074 AK308550 BC111844 AAI11845 BC136280 AAI36281 BC143777 BC143779 L76627 AAB05337 L76631 AAB05338 U31215 AAA87843 U31216 AAA87844 XM_011535782 XP_011534084 XM_011535783 XP_011534085 XM_011535784 XP_011534086 NM_001278064 NP_001264993 NM_001278065 NP_001264994 NM_001278066 NP_001264995 NM_001278067 NP_001264996 NM_000838 NP_000829 NM_001114329 |
| Function | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. {ECO:0000269|PubMed:24603153, ECO:0000269|PubMed:7476890}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:24603153}; Multi-pass membrane protein {ECO:0000269|PubMed:24603153}. |
| Tissue Specificity | Detected in brain. |
| Top Pathways | Calcium signaling pathway, Glutamatergic synapse, Long-term depression, Retrograde endocannabinoid signaling, Long-term potentiation |