| Gene Symbol | SSX2IP |
|---|---|
| Entrez Gene | 117178 |
| Alt Symbol | ADIP |
| Species | Human |
| Gene Type | protein-coding |
| Description | synovial sarcoma, X breakpoint 2 interacting protein |
| Other Description | SSX2-interacting protein|afadin DIL domain-interacting protein|afadin- and alpha-actinin-binding protein |
| Swissprots | B4DFE3 Q9UIX0 Q7L168 J3KR02 A8K8W0 Q9Y2D8 Q6ULS1 D3DT13 Q6P2P8 |
| Accessions | EAW73223 EAW73224 EAW73225 EAW73226 EAW73227 EAW73228 Q9Y2D8 AB023140 BAA76767 AK001710 BAG50966 AK021515 AK023097 AK093173 BAG52668 AK292475 BAF85164 AK294057 BAG57404 AK307336 AK316472 BAH14843 AL133046 CAB61373 AM393642 CAL38518 AY367055 AAQ72373 AY651262 BC033637 AAH33637 BC035580 BC064389 AAH64389 DQ891136 ABM82062 DQ894315 ABM85241 XM_005270427 XP_005270484 XM_005270428 XP_005270485 XM_005270429 XP_005270486 XM_006710331 XP_006710394 XM_011540610 XP_011538912 XM_011540611 XP_011538913 XM_011540612 XP_011538914 XR_946540 NM_001166293 NP_001159765 NM_001166294 NP_001159766 NM_001166295 NP_001159767 NM_001166417 NP_001159889 NM_014021 NP_054740 |
| Function | Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E- cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles (PubMed:23816619). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitement of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449). {ECO:0000250|UniProtKB:Q8VC66, ECO:0000269|PubMed:23816619, ECO: |
| Subcellular Location | Cell junction, adherens junction {ECO:0000250}. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:23816619, ECO:0000269|PubMed:24356449}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24356449}. Note=Not found at cell-matrix AJs. {ECO:0000250}. |
| Tissue Specificity | Widely expressed, with the highest expression in brain, intermediate expression in kidney, testis, spinal cord, liver, heart, lung, skeletal muscle, ovary, fetal liver and fetal brain, and little to no expression in pancreas and spleen. All specific brain regions showed intermediate to high expression, with highest expression in amygdala. Also expressed in fetal tissues, mainly in liver and brain. |
| Top Pathways | Adherens junction |
Afadin- and alpha-actinin-binding protein (SSX2IP), Human, ELISA Kit - E01A1990 from ARP American Research Products
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SSX2IP (Human) IP-WB Antibody Pair - H00117178-PW1 from Acris Antibodies
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Afadin and Alpha actinin binding protein (SSX2IP), ELISA Kit - MBS7218609 from MyBioSource
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Afadin- and Alpha actinin-binding protein (SSX2IP), ELISA Kit - MBS7237497 from MyBioSource
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Afadin- and alpha-actinin-binding protein (SSX2IP), ELISA Kit - MBS7241732 from MyBioSource
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Afadin- and alpha-actinin-binding protein (SSX2IP), ELISA Kit - MBS7229452 from MyBioSource
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Afadin- and alpha-actinin-binding protein (SSX2IP), ELISA Kit - MBS7214112 from MyBioSource
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Afadin- and alpha-actinin-binding protein (SSX2IP), ELISA Kit - MBS7212615 from MyBioSource
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Afadin- and alpha-actinin-binding protein (SSX2IP), ELISA Kit - MBS7245440 from MyBioSource
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Afadin- and alpha-actinin-binding protein (SSX2IP), ELISA Kit - MBS7204232 from MyBioSource
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Afadin- and alpha-actinin-binding protein (SSX2IP), ELISA Kit - MBS7212242 from MyBioSource
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Afadin- and alpha-actinin-binding protein (SSX2IP), ELISA Kit - MBS7216095 from MyBioSource
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Afadin- and alpha-actinin-binding protein (SSX2IP), ELISA Kit - MBS7217131 from MyBioSource
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Afadin- and alpha-actinin-binding protein (SSX2IP), ELISA Kit - MBS7244530 from MyBioSource
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Human SSX2IP ELISA Kit - E001132 from Biobool
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anti-SSX2IP antibody - ARG63433 from Arigo Biolaboratories
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