SSX2IP

Gene Symbol	SSX2IP
Entrez Gene	117178
Alt Symbol	ADIP
Species	Human
Gene Type	protein-coding
Description	synovial sarcoma, X breakpoint 2 interacting protein
Other Description	SSX2-interacting protein|afadin DIL domain-interacting protein|afadin- and alpha-actinin-binding protein
Swissprots	B4DFE3 Q9UIX0 Q7L168 J3KR02 A8K8W0 Q9Y2D8 Q6ULS1 D3DT13 Q6P2P8
Accessions	EAW73223 EAW73224 EAW73225 EAW73226 EAW73227 EAW73228 Q9Y2D8 AB023140 BAA76767 AK001710 BAG50966 AK021515 AK023097 AK093173 BAG52668 AK292475 BAF85164 AK294057 BAG57404 AK307336 AK316472 BAH14843 AL133046 CAB61373 AM393642 CAL38518 AY367055 AAQ72373 AY651262 BC033637 AAH33637 BC035580 BC064389 AAH64389 DQ891136 ABM82062 DQ894315 ABM85241 XM_005270427 XP_005270484 XM_005270428 XP_005270485 XM_005270429 XP_005270486 XM_006710331 XP_006710394 XM_011540610 XP_011538912 XM_011540611 XP_011538913 XM_011540612 XP_011538914 XR_946540 NM_001166293 NP_001159765 NM_001166294 NP_001159766 NM_001166295 NP_001159767 NM_001166417 NP_001159889 NM_014021 NP_054740
Function	Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E- cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles (PubMed:23816619). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitement of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449). {ECO:0000250|UniProtKB:Q8VC66, ECO:0000269|PubMed:23816619, ECO:
Subcellular Location	Cell junction, adherens junction {ECO:0000250}. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:23816619, ECO:0000269|PubMed:24356449}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24356449}. Note=Not found at cell-matrix AJs. {ECO:0000250}.
Tissue Specificity	Widely expressed, with the highest expression in brain, intermediate expression in kidney, testis, spinal cord, liver, heart, lung, skeletal muscle, ovary, fetal liver and fetal brain, and little to no expression in pancreas and spleen. All specific brain regions showed intermediate to high expression, with highest expression in amygdala. Also expressed in fetal tissues, mainly in liver and brain.
Top Pathways	Adherens junction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SSX2IP full length protein - ab132030 from Abcam Category Protein Source Wheat germ Species Human

Human SSX2IP peptide - ab23199 from Abcam Category Peptide Species Human

SSX2IP Antibody Blocking Peptide - LS-E19411 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SSX2IP Antibody Blocking Peptide - LS-E25692 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SSX2IP Protein - H00117178-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SSX2IP-Antibody-Center-Blocking-peptide - BP5444c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SSX2IP-Antibody-N-term-Blocking-peptide - BP5521a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SSX2IP blocking peptide - GTX10256-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog

SSX2IP Blocking Peptide - 33R-4706 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SSX2IP Peptide - AC21-0523-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SSX2IP / ADIP - H00117178-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SSX2IP / ADIP - H00117178-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SSX2IP Peptide - 46-435P from ProSci Category Peptide Species Human

SSX2IP fusion protein - ag4584 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

SSX2IP fusion protein - ag6942 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human Afadin- and alpha-actinin-binding protein(SSX2IP) - CSB-YP897526HU CSB-EP897526HU CSB-BP897526HU CSB-MP897526HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Afadin- and alpha-actinin-binding protein (Ssx2ip) - MBS1446208 from MyBioSource Category Protein Prices $2,380.00, $2,380.00, $2,800.00, $2,800.00 Sizes 1 mg (E Coli Derived), 100 µg (Baculovirus Derived), 1 mg (Yeast Derived), 100 µg (Mammalian Cell Derived) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

SSX2IP / ADIP (full length, N-term HIS tag, transcript variant 5) - TP760902 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

SSX2IP, Peptide - MBS425391 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Dog

SSX2IP Recombinant Protein Antigen - NBP1-85956PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SSX2IP Peptide, Human - M34GP15222H from Creative Peptides Category Peptide Source Synthetic. Species Human

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