PELP1

Gene Symbol PELP1
Entrez Gene 27043
Alt Symbol MNAR, P160
Species Human
Gene Type protein-coding
Description proline, glutamate and leucine rich protein 1
Other Description modulator of non-genomic activity of estrogen receptor|proline and glutamic acid rich nuclear protein|proline-, glutamic acid- and leucine-rich protein 1|transcription factor HMX3
Swissprots Q5EGN3 Q96FT1 Q6NTE6 Q8IZL8 O15450 Q9BU60
Accessions EAW90424 EAW90425 EAW90426 Q8IZL8 AF547989 AAN41255 AI927300 AK226056 AK291163 BAF83852 AK293838 BAG57238 AK299084 BAG61148 AY882602 AAW80659 BC002875 AAH02875 BC010457 AAH10457 BC039131 BC069058 AAH69058 BI752899 DC417876 U88153 AAC17708 U88154 AAC17709 NM_001278241 NP_001265170 NM_014389 NP_055204
Function Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence- specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and
Subcellular Location Nucleus, nucleoplasm {ECO:0000250}. Nucleus. Cytoplasm. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasm (By similarity). Also found associated with the plasma membrane. Mainly in cytoplasm in a subset of breast tumors. Localization is widely deregulated in endometrial cancers with predominantly cytoplasm localization in high-grade endometrial tumors. {ECO:0000250}.
Tissue Specificity Isoform 2 is expressed in breast cancer cell lines. Isoform 1 is widely expressed. {ECO:0000269|PubMed:11481323}.

PELP1 Antibody - 13783 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from SW620 cells, HeLa cells, and human endometrium using PELP1 Antibody.

PELP1 (D-5) - sc-393534 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PELP1 (D-5): sc-393534. Western blot analysis of PELP1 expression in HeLa whole cell lysate.

PELP1 (E-1) - sc-390599 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PELP1 (E-1): sc-390599. Western blot analysis of PELP1 expression in HeLa whole cell lysate.

PELP1 (E-15) - sc-34187 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PELP1 (E-15): sc-34187. Western blot analysis of PELP1 expression in mouse testis tissue extract.

PELP1 (N-19) - sc-34182 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PELP1 (N-19): sc-34182. Western blot analysis of PELP1 expression in non-transfected: sc-117752 (A) and human PELP1 transfected: sc-117220 (B) 293T whole cell lysates.

PELP1 (R-17) - sc-34183 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PELP1 (H-300) - sc-67027 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PELP1 (H-300): sc-67027. Western blot analysis of PELP1 expression in non-transfected 293T: sc-117752 (A), human PELP1 transfected 293T: sc-117220 (B) and HeLa (C) whole cell lysates.

Anti-PELP1 antibody - ab32912 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PELP1 antibody (ab32912) at 1 µg/mlLane 1 : MCF7 (Human breast adenocarcinoma cell line) Whole Cell LysateLane 2 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-PELP1 antibody - ab185701 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PELP1 antibody (ab185701) at 1/500 dilution + HeLa cell lysate

Anti-PELP1 antibody - ab170525 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PELP1 antibody (ab170525) at 1/100 dilution + Mouse spleen tissue lysate at 35 µg

Anti-PELP1 antibody - ab84094 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human MNAR by Immunohistochemistry.Sample: FFPE section of Human breast adenocarcinoma.Antibody: ab84094 used at a dilution of 1/500.

Anti-PELP1 antibody - ab70798 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human testicular seminoma tissue labelling PELP1 with ab70798 at 1/1000 (1µg/ml). Detection: DAB.

Anti-PELP1 antibody [EPR15212] - ab187653 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR15212
Immunohistochemical analysis of formalin fixed and paraffin embedded rat brain tissue labeling PELP1 with ab187653 at 1/100 dilution, counterstained with Hematoxylin.

Anti-PELP1 Antibody (aa1000-1050) - LS-C285941 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Mouse PELP1/MNAR by Immunohistochemistry. Sample: FFPE section of mouse ovary. Antibody: Affinity purified rabbit anti-PELP1/MNAR used at a dilution of 1:100. Detection: DAB.

Anti-PELP1 Antibody (aa1000-1050) - LS-C287103 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human and Mouse PELP1/MNAR by Immunohistochemistry. Sample: FFPE sections of human ovarian carcinoma (left) and mouse renal cell carcinoma (right). Antibody: Affinity purified rabbit anti-PELP1/MNAR used at a dilution of 1:5000 (0.2 ug/ml) and 1:1000 (1 ug/ml). Detection: DAB.

Anti-PELP1 Antibody - LS-C332411 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human rectal cancer tissue using PELP1 antibody at dilution of 1:200 (x400 lens).

Anti-PELP1 Antibody (aa1000-1050) - LS-C93158 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PELP1 Antibody (aa25-75) - LS-C93159 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PELP1 Antibody (aa744-771, AP) - LS-C216689 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PELP1 Antibody (aa744-771, APC) - LS-C216690 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PELP1 Antibody (aa744-771, Biotin) - LS-C216691 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PELP1 Antibody (aa744-771, Azide-free, HRP) - LS-C216693 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PELP1 Antibody (aa744-771, FITC) - LS-C216692 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PELP1 Antibody (aa744-771, PE) - LS-C216694 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PELP1 Antibody (C-Terminus, AP) - LS-C220298 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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