| Gene Symbol |
PELP1
|
| Entrez Gene |
27043
|
| Alt Symbol |
MNAR, P160
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
proline, glutamate and leucine rich protein 1
|
| Other Description |
modulator of non-genomic activity of estrogen receptor|proline and glutamic acid rich nuclear protein|proline-, glutamic acid- and leucine-rich protein 1|transcription factor HMX3
|
| Swissprots |
Q5EGN3 Q96FT1 Q6NTE6 Q8IZL8 O15450 Q9BU60
|
| Accessions |
EAW90424 EAW90425 EAW90426 Q8IZL8 AF547989 AAN41255 AI927300 AK226056 AK291163 BAF83852 AK293838 BAG57238 AK299084 BAG61148 AY882602 AAW80659 BC002875 AAH02875 BC010457 AAH10457 BC039131 BC069058 AAH69058 BI752899 DC417876 U88153 AAC17708 U88154 AAC17709 NM_001278241 NP_001265170 NM_014389 NP_055204
|
| Function |
Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence- specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and
|
| Subcellular Location |
Nucleus, nucleoplasm {ECO:0000250}. Nucleus. Cytoplasm. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasm (By similarity). Also found associated with the plasma membrane. Mainly in cytoplasm in a subset of breast tumors. Localization is widely deregulated in endometrial cancers with predominantly cytoplasm localization in high-grade endometrial tumors. {ECO:0000250}.
|
| Tissue Specificity |
Isoform 2 is expressed in breast cancer cell lines. Isoform 1 is widely expressed. {ECO:0000269|PubMed:11481323}.
|