Gene Symbol | MTNR1B |
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Entrez Gene | 4544 |
Alt Symbol | FGQTL2, MEL-1B-R, MT2 |
Species | Human |
Gene Type | protein-coding |
Description | melatonin receptor 1B |
Other Description | mel1b receptor|melatonin receptor MEL1B|melatonin receptor type 1B |
Swissprots | P49286 |
Accessions | BAA92315 EAW66891 P49286 AF467654 AAL75503 AY114100 AAM78367 AY521019 AAS00461 BC069163 AAH69163 U25341 AAC50612 XM_011542839 XP_011541141 NM_005959 NP_005950 |
Function | High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Expressed in retina and less in brain and hippocampus. |
Top Pathways | Circadian entrainment, Neuroactive ligand-receptor interaction |
MEL-1B-R CRISPR/Cas9 KO Plasmid (h) - sc-401526 from Santa Cruz Biotechnology
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MEL-1B-R HDR Plasmid (h) - sc-401526-HDR from Santa Cruz Biotechnology
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MEL-1B-R Double Nickase Plasmid (h) - sc-401526-NIC from Santa Cruz Biotechnology
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MEL-1B-R Double Nickase Plasmid (h2) - sc-401526-NIC-2 from Santa Cruz Biotechnology
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MEL-1B-R CRISPR Activation Plasmid (h) - sc-401526-ACT from Santa Cruz Biotechnology
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MEL-1B-R CRISPR Activation Plasmid (h2) - sc-401526-ACT-2 from Santa Cruz Biotechnology
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MEL-1B-R Lentiviral Activation Particles (h) - sc-401526-LAC from Santa Cruz Biotechnology
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MEL-1B-R Lentiviral Activation Particles (h2) - sc-401526-LAC-2 from Santa Cruz Biotechnology
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MEL-1B-R siRNA (h) - sc-40114 from Santa Cruz Biotechnology
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MEL-1B-R shRNA Plasmid (h) - sc-40114-SH from Santa Cruz Biotechnology
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MEL-1B-R shRNA (h) Lentiviral Particles - sc-40114-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN14726 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14726 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05084 from Sigma-Aldrich
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MTNR1B siRNA (Human) - CRH3014 from Cohesion Biosciences
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Melatonin Receptor 1B RNAi - H00004544-R02 from Novus Biologicals
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shRNA set against Human MTNR1B (NM_005959.3) - SHH346580 from Creative biogene
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Human MTNR1B siRNA - orb263516 from Biorbyt
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MTNR1B shRNA Plasmid (Human) - CHH3014 from Cohesion Biosciences
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MTNR1B miRNA 3'UTR clone - MiUTR1H-06521 from Creative biogene
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