Gene Symbol | Sec61a2 |
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Entrez Gene | 57743 |
Alt Symbol | - |
Species | Mouse |
Gene Type | protein-coding |
Description | Sec61, alpha subunit 2 (S. cerevisiae) |
Other Description | Sec61 alpha|protein transport protein Sec61 subunit alpha|protein transport protein Sec61 subunit alpha isoform 2|sec61 alpha-2 |
Swissprots | Q9JLR1 |
Accessions | EDL07972 EDL07973 Q9JLR1 AF145254 AAF66696 AF222748 AAG44253 AK017615 BAB30840 AK077701 BAC36967 AK136447 AK160602 AK161316 BAE36319 BC005458 AAH05458 XM_006497515 XP_006497578 XM_006497516 XP_006497579 XM_006497517 XP_006497580 XR_373943 NM_021305 NP_067280 |
Function | Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity). {ECO:0000250}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Top Pathways | Protein export, Phagosome, Protein processing in endoplasmic reticulum |
Sec61α2 CRISPR/Cas9 KO Plasmid (m) - sc-425419 from Santa Cruz Biotechnology
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Sec61α2 HDR Plasmid (m) - sc-425419-HDR from Santa Cruz Biotechnology
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Sec61α2 Double Nickase Plasmid (m) - sc-425419-NIC from Santa Cruz Biotechnology
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Sec61α2 Double Nickase Plasmid (m2) - sc-425419-NIC-2 from Santa Cruz Biotechnology
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Sec61α2 CRISPR Activation Plasmid (m) - sc-425419-ACT from Santa Cruz Biotechnology
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Sec61α2 CRISPR Activation Plasmid (m2) - sc-425419-ACT-2 from Santa Cruz Biotechnology
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Sec61α2 Lentiviral Activation Particles (m) - sc-425419-LAC from Santa Cruz Biotechnology
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Sec61α2 Lentiviral Activation Particles (m2) - sc-425419-LAC-2 from Santa Cruz Biotechnology
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Sec61α2 siRNA (m) - sc-153318 from Santa Cruz Biotechnology
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Sec61α2 shRNA Plasmid (m) - sc-153318-SH from Santa Cruz Biotechnology
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Sec61α2 shRNA (m) Lentiviral Particles - sc-153318-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU065501 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN40868 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND40868 from Sigma-Aldrich
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SEC61A2 siRNA (Mouse) - CRM6036 from Cohesion Biosciences
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SEC61A2 - MBS8241005 from MyBioSource
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shRNA set against Mouse SEC61A2 (NM_021305.3) - SHH403896 from Creative biogene
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Mouse SEC61A2 siRNA - orb285512 from Biorbyt
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SEC61A2 shRNA Plasmid (Mouse) - CHM6036 from Cohesion Biosciences
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SEC61A2 miRNA 3'UTR clone - MiUTR1M-10511 from Creative biogene
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