| Gene Symbol |
Tbpl2
|
| Entrez Gene |
227606
|
| Alt Symbol |
Gm348, Trf3
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
TATA box binding protein like 2
|
| Other Description |
TATA box-binding protein-like protein 2|TATA box-binding protein-related factor 3|TBP-like protein 2|TBP-related factor 3 (Trf3)|tbpl2
|
| Swissprots |
Q498A1 A2AQK6 Q6SJ95
|
| Accessions |
EDL08159 Q6SJ95 AY457924 AAR24282 BC100305 AAI00306 BC119160 AAI19161 BC144904 AAI44905 BC144905 BK005773 DAA06033 NM_001289689 NP_001276618 NM_199059 NP_951014 NR_110359
|
| Function |
Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process. {ECO:0000269|PubMed:17704303}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250|UniProtKB:Q6SJ96, ECO:0000269|PubMed:17704303}. Nucleus {ECO:0000250|UniProtKB:Q6SJ96, ECO:0000269|PubMed:17704303}. Note=Present in the cytoplasm during cytokenesis. {ECO:0000250|UniProtKB:Q6SJ96}.
|
| Tissue Specificity |
Expressed in myotubes and myofibers (at protein level). Expressed in a wide variety of tissues with highest levels in heart, lung, liver, uterus and placenta and especially the gonads. Expression is higher in the ovary than the testis, and within the ovary expression is localized to the oocytes. {ECO:0000269|PubMed:14634207, ECO:0000269|PubMed:15062100, ECO:0000269|PubMed:16412700, ECO:0000269|PubMed:17704303}.
|
| Top Pathways |
Huntington's disease, HTLV-I infection, Herpes simplex infection, Viral carcinogenesis, Epstein-Barr virus infection
|