Gene Symbol | Tbpl2 |
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Entrez Gene | 227606 |
Alt Symbol | Gm348, Trf3 |
Species | Mouse |
Gene Type | protein-coding |
Description | TATA box binding protein like 2 |
Other Description | TATA box-binding protein-like protein 2|TATA box-binding protein-related factor 3|TBP-like protein 2|TBP-related factor 3 (Trf3)|tbpl2 |
Swissprots | Q498A1 A2AQK6 Q6SJ95 |
Accessions | EDL08159 Q6SJ95 AY457924 AAR24282 BC100305 AAI00306 BC119160 AAI19161 BC144904 AAI44905 BC144905 BK005773 DAA06033 NM_001289689 NP_001276618 NM_199059 NP_951014 NR_110359 |
Function | Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process. {ECO:0000269|PubMed:17704303}. |
Subcellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q6SJ96, ECO:0000269|PubMed:17704303}. Nucleus {ECO:0000250|UniProtKB:Q6SJ96, ECO:0000269|PubMed:17704303}. Note=Present in the cytoplasm during cytokenesis. {ECO:0000250|UniProtKB:Q6SJ96}. |
Tissue Specificity | Expressed in myotubes and myofibers (at protein level). Expressed in a wide variety of tissues with highest levels in heart, lung, liver, uterus and placenta and especially the gonads. Expression is higher in the ovary than the testis, and within the ovary expression is localized to the oocytes. {ECO:0000269|PubMed:14634207, ECO:0000269|PubMed:15062100, ECO:0000269|PubMed:16412700, ECO:0000269|PubMed:17704303}. |
Top Pathways | Huntington's disease, HTLV-I infection, Herpes simplex infection, Viral carcinogenesis, Epstein-Barr virus infection |
TBPL2 CRISPR/Cas9 KO Plasmid (m) - sc-432706 from Santa Cruz Biotechnology
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TBPL2 HDR Plasmid (m) - sc-432706-HDR from Santa Cruz Biotechnology
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TBPL2 Double Nickase Plasmid (m) - sc-432706-NIC from Santa Cruz Biotechnology
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TBPL2 Double Nickase Plasmid (m2) - sc-432706-NIC-2 from Santa Cruz Biotechnology
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TBPL2 CRISPR Activation Plasmid (m) - sc-432706-ACT from Santa Cruz Biotechnology
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TBPL2 CRISPR Activation Plasmid (m2) - sc-432706-ACT-2 from Santa Cruz Biotechnology
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TBPL2 Lentiviral Activation Particles (m) - sc-432706-LAC from Santa Cruz Biotechnology
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TBPL2 Lentiviral Activation Particles (m2) - sc-432706-LAC-2 from Santa Cruz Biotechnology
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TBPL2 siRNA (m) - sc-154123 from Santa Cruz Biotechnology
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TBPL2 shRNA Plasmid (m) - sc-154123-SH from Santa Cruz Biotechnology
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TBPL2 shRNA (m) Lentiviral Particles - sc-154123-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN42578 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND42578 from Sigma-Aldrich
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TBPL2 siRNA (Mouse) - CRN2589 from Cohesion Biosciences
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TBPL2 - MBS8221149 from MyBioSource
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shRNA set against Mouse Tbpl2 (NM_199059.1) - SHH424292 from Creative biogene
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shRNA set against Mouse Tbpl2(NM_199059.1) - SHL059808 from Creative biogene
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Mouse TBPL2 siRNA - orb292064 from Biorbyt
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TBPL2 shRNA Plasmid (Mouse) - CHN2589 from Cohesion Biosciences
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TBPL2 miRNA 3'UTR clone - MiUTR1M-11590 from Creative biogene
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