TLK1

Gene Symbol TLK1
Entrez Gene 9874
Alt Symbol PKU-beta
Species Human
Gene Type protein-coding
Description tousled-like kinase 1
Other Description SNARE protein kinase SNAK|serine threonine protein kinase|serine/threonine-protein kinase tousled-like 1
Swissprots Q14150 Q8N591 Q9Y4F6 Q9NYH2 B4DX87 B3KR15 Q9UKI8
Accessions AAX93162 AAY15077 EAX11220 EAX11221 EAX11222 EAX11223 Q9UKI8 AB004885 BAA20562 AF162666 AAF03094 AF246219 AAF71263 AK090779 BAG52227 AK091975 BAG52453 AK292508 BAF85197 AK301857 BAG63299 BC032657 AAH32657 BX537631 D50927 BAA09486 DA144429 DN604386 DQ890904 ABM81830 DQ894057 ABM84983 Z25421 CAA80908 XM_005246981 XP_005247038 XM_011512238 XP_011510540 XR_923070 NM_001136554 NP_001130026 NM_001136555 NP_001130027 NM_012290 NP_036422
Function Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S- phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}.
Subcellular Location Nucleus {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:9427565}.
Tissue Specificity Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined. {ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:9427565}.

Phospho-TLK1 (Ser743) Antibody - 4121 from Cell Signaling Technology

Prices $279.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, untreated or treated overnight with hydroxyurea or aphidicolin, using Phospho-TLK1 (Ser743) Antibody (upper), or TLK1 Antibody #4125 (lower).

TLK1 Antibody - 4125 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa (human), C6 (rat), and RAW 264.7 (mouse) cells, using TLK1 Antibody.

TLK1 (G-8) - sc-393515 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TLK1 (G-8): sc-393515. Western blot analysis of TLK1 expression in HeLa (A), C6 (C) and RAW 264.7 (D) whole cell lysates, HeLa nuclear extract (B) and human testis tissue extract (E). Note lack of reativity in lanes B and C.

TLK (F-20) - sc-11595 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TLK (F-20): sc-11595. Western blot analysis of TLK expression in rat testis tissue extract.

TLK (C-19) - sc-11596 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TLK (C-19): sc-11596. Western blot analysis of TLK expression in Jurkat nuclear extract.

TLK1 (A-15) - sc-79281 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TLK1 (A-15): sc-79281. Western blot analysis of TLK1 expression in HeLa (A) and Jurkat (B) nuclear extracts.

TLK1 (C-20) - sc-79282 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TLK1 (V-17) - sc-11594 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TLK1 (V-17): sc-11594. Western blot analysis of TLK1 expression in non-transfected 293T: sc-117752 (A), human TLK1 transfected 293T: sc-159028 (B) and HeLa (C) whole cell lysates.

TLK1 (P-17) - sc-79284 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TLK1 (P-17): sc-79284. Western blot analysis of TLK1 expression in HeLa nuclear extract.

TLK1 (N-18) - sc-11591 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TLK1 (D-15) - sc-11592 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TLK1 (D-15): sc-11592. Western blot analysis of TLK1 expression in Jurkat nuclear extract.

TLK1 (S-32) - sc-100345 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
TLK1 (S-32): sc-100345. Western blot analysis of TLK1 expression in HeLa whole cell lysate.

Anti-TLK1 (phospho S743) antibody - ab191509 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TLK1 (phospho S743) antibody (ab191509)Lane 1 : MCF-7 whole cell lysateLane 2 : Rat brain tissue lysateLane 3 : H9C2 whole cell lysate

Anti-TLK1 antibody - ab155823 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-TLK1 antibody (ab155823) at 1/500 dilution + 293T whole cell lysate at 30 µg

Anti-TLK1 antibody - ab102043 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-TLK1 antibody (ab102043) at 1 µg/ml + ACHN cell lysate at 10 µg

Anti-TLK1 antibody - ab63629 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of COS7 cells using ab63629 at a dilution of 1/500-1/1000. Samples were untreated (left hand panel) or treated (right hand panel) with the immunizing peptide.

Anti-TLK1 antibody - ab56879 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-TLK1 antibody [EPR2886] - ab108987 from Abcam

Prices $304.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2886
All lanes : Anti-TLK1 antibody [EPR2886] (ab108987) at 1/1000 dilutionLane 1 : HeLa cell lysate Lane 2 : A431 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit IgG at 1/2000 dilution

Anti-TLK1 antibody - C-terminal - ab71744 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TLK1 antibody - C-terminal (ab71744) at 1/100 dilution + HL-60 cell lysate at 12.5 µg

Anti-TLK1 antibody - N-terminal - ab157159 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-TLK1 antibody - N-terminal (ab157159) at 1/500 dilutionLane 1 : HeLa total cell extractLane 2 : Jurkat total cell extractLane 3 : Mouse thymus total cell extract

Anti-TLK1 Antibody (C-Terminus) - LS-C10636 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TLK1 Antibody (aa701-728, AP) - LS-C271584 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TLK1 Antibody (aa701-728, APC) - LS-C271585 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TLK1 Antibody (aa701-728, Biotin) - LS-C271586 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TLK1 Antibody (aa701-728, FITC) - LS-C271587 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Search more