Gene Symbol | CLSTN3 |
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Entrez Gene | 9746 |
Alt Symbol | CDHR14, CSTN3, alcbeta |
Species | Human |
Gene Type | protein-coding |
Description | calsyntenin 3 |
Other Description | alc-beta|alcadein beta|alcadein-beta|cadherin-related family member 14|calsyntenin-3 |
Swissprots | D3DUT6 O94831 Q9BQT9 Q2T9J5 Q5UE57 |
Accessions | EAW88676 EAW88677 EAW88678 EAW88679 EAW88680 Q9BQT9 AA864252 AB018269 BAA34446 AJ277460 CAC33084 AK299177 BAG61223 AK299246 BAG61277 AK316059 BAH14430 AY753302 AAV30552 BC039075 AAH39075 BC104767 AAI04768 BC111491 AAI11492 BC112283 AAI12284 BC148258 AAI48259 DA092023 XM_006719163 XP_006719226 NM_014718 NP_055533 |
Function | May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Endoplasmic reticulum membrane. Golgi apparatus membrane. Note=Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization. {ECO:0000250}. |
Tissue Specificity | According to PubMed:12498782, expressed predominantly in the brain and in kidney. Low levels in heart, skeletal muscle, liver, placenta, pancreas and lung. According to PubMed:12972431, predominant expression in brain, and only marginal in kidney. In brain, present throughout all cortical layers, highest levels in GABAergic neurons (based on morphology and distribution pattern). {ECO:0000269|PubMed:12498782, ECO:0000269|PubMed:12972431}. |
calsyntenin-3 CRISPR/Cas9 KO Plasmid (h) - sc-405630 from Santa Cruz Biotechnology
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calsyntenin-3 HDR Plasmid (h) - sc-405630-HDR from Santa Cruz Biotechnology
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calsyntenin-3 Double Nickase Plasmid (h) - sc-405630-NIC from Santa Cruz Biotechnology
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calsyntenin-3 Double Nickase Plasmid (h2) - sc-405630-NIC-2 from Santa Cruz Biotechnology
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calsyntenin-3 CRISPR Activation Plasmid (h) - sc-405630-ACT from Santa Cruz Biotechnology
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calsyntenin-3 CRISPR Activation Plasmid (h2) - sc-405630-ACT-2 from Santa Cruz Biotechnology
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calsyntenin-3 Lentiviral Activation Particles (h) - sc-405630-LAC from Santa Cruz Biotechnology
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calsyntenin-3 Lentiviral Activation Particles (h2) - sc-405630-LAC-2 from Santa Cruz Biotechnology
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calsyntenin-3 siRNA (h) - sc-95768 from Santa Cruz Biotechnology
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calsyntenin-3 shRNA Plasmid (h) - sc-95768-SH from Santa Cruz Biotechnology
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calsyntenin-3 shRNA (h) Lentiviral Particles - sc-95768-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU124471 from Sigma-Aldrich
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MISSION® esiRNA - EHU096341 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6268 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6268 from Sigma-Aldrich
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CLSTN3 siRNA (Human) - CRH6513 from Cohesion Biosciences
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Calsyntenin-3 RNAi - H00009746-R01 from Novus Biologicals
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CLSTN3 - MBS8204866 from MyBioSource
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shRNA set against Human CLSTN3 (NM_014718.3) - SHH265721 from Creative biogene
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shRNA set against Human CLSTN3(NM_014718.3) - SHG184471 from Creative biogene
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Human CLSTN3 siRNA - orb267015 from Biorbyt
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CLSTN3 shRNA Plasmid (Human) - CHH6513 from Cohesion Biosciences
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CLSTN3 miRNA 3'UTR clone - MiUTR1H-02241 from Creative biogene
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