CFLAR

Gene Symbol	CFLAR
Entrez Gene	8837
Alt Symbol	CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS
Species	Human
Gene Type	protein-coding
Description	CASP8 and FADD-like apoptosis regulator
Other Description	FADD-like antiapoptotic molecule 1|MACH-related inducer of toxicity|caspase homolog|caspase-eight-related protein|caspase-like apoptosis regulatory protein|caspase-related inducer of apoptosis|cellular FLICE-like inhibitory protein|inhibitor of FLICE|usurpin beta
Swissprots	O43620 B4DJE0 Q54AF1 O60459 O43618 O14673 O14675 Q9UEW1 O14674 O15356 O43619 O15519 O15510 O15137 Q96TE4 O15138 B7Z9F9 Q53TS6 O60458
Accessions	AAY24290 BAB32551 BAB32552 CCA94581 EAW70235 EAW70236 EAW70237 EAW70238 EAW70239 EAW70240 EAW70241 EAW70242 EAW70243 EAW70244 EAW70245 O15519 AB209600 BAD92837 AF005774 AAC15825 AF005775 AAC15826 AF009616 AAB70909 AF009617 AAB70910 AF009618 AAB70911 AF009619 AAB70912 AF010127 AAB64110 AF015450 AAC16439 AF015451 AAC16440 AF015452 AAC16441 AF041458 AAB99790 AF041459 AAB99791 AF041460 AAB99792 AF041461 AAB99793 AF041462 AAB99794 AK124664 AK125394 AK289913 BAF82602 AK296036 BAG58802 AK297387 BAG59828 AK304585 BAG65373 AK308767 AK315208 BAG37645 AK315924 BAH14295 AL365413 BC001602 AAH01602 BM969271 BT006751 AAP35397 BX457155 CB148618 CD699251 DC321068 DC375144 DQ890592 ABM92209 DQ893760 ABM84686 U85059 AAB82648 U97074 AAC51622 U97075 AAC51623 Y14039 CAA74366 Y14040 CAA74367 XM_005246937 XP_005246994 XM_005246938 XP_005246995 XM_011512100 XP_011510402 NM_001127183 NP_001120655 NM_001127184 NP_001120656 NM_001202515 NP_001189444 NM_001202516 NP_001189445 NM_001202517 NP_001189446 NM_001202518 NP_001189447 NM_001202519 NP_001189448 NM_001308042 NP_001294971 NM_001308043 NP_001294972 NM_003879 NP_003870
Function	Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. {ECO:0000269|PubMed:9880531}.
Tissue Specificity	Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.
Top Pathways	Apoptosis, Chagas disease (American trypanosomiasis), TNF signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® FLIP siRNA II - 12407 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® FLIP siRNA I - 12372 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

FLIP S/L CRISPR/Cas9 KO Plasmid (h) - sc-400400 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

FLIP S/L HDR Plasmid (h) - sc-400400-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FLIP S/L Double Nickase Plasmid (h) - sc-400400-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FLIP S/L Double Nickase Plasmid (h2) - sc-400400-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FLIP S/L CRISPR Activation Plasmid (h) - sc-400400-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

FLIP S/L CRISPR Activation Plasmid (h2) - sc-400400-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

FLIP S/L Lentiviral Activation Particles (h) - sc-400400-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FLIP S/L Lentiviral Activation Particles (h2) - sc-400400-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FLIP S/L siRNA (h) - sc-35388 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

FLIP S/L shRNA Plasmid (h) - sc-35388-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

FLIP S/L shRNA (h) Lentiviral Particles - sc-35388-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

FLIP RNAi - H00008837-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU093481 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1011 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1011 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03852 from Sigma-Aldrich Category miRNA

CFLAR siRNA (Human) - CRH5833 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CFLAR - MBS8214748 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human CFLAR (NM_003879.5) - SHH262505 from Creative biogene Category siRNA Species Reactivities Human

CFLAR shRNA Plasmid (Human) - CHH5833 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

CFLAR miRNA 3'UTR clone - MiUTR3H-06101 from Creative biogene Species Reactivities Human

CFLAR miRNA 3'UTR clone - MiUTR3H-06102 from Creative biogene Species Reactivities Human

CFLAR miRNA 3'UTR clone - MiUTR3H-06103 from Creative biogene Species Reactivities Human

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