| Gene Symbol |
Chst15
|
| Entrez Gene |
77590
|
| Alt Symbol |
4631426J05Rik, BRAG, GalNAcS-6ST, MAd5, mKIAA0598
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
|
| Other Description |
B-cell RAG-associated gene protein|GalNAc 4-sulfate 6-O-sulfotransferase|GalNAc4S-6ST|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase|carbohydrate sulfotransferase 15
|
| Swissprots |
Q8BLQ5 Q80TW4 Q91XQ5 Q9D2N6
|
| Accessions |
EDL17724 EDL17725 EDL17726 Q91XQ5 AB187269 BAD89559 AF320786 AAK69604 AK019474 BAB31743 AK031745 AK031995 AK035637 BAC29133 AK043803 BAC31658 AK082318 BAC38463 AK083614 BAC38968 AK122324 BAC65606 BC031443 AAH31443 XM_006508332 XP_006508395 XM_006508333 XP_006508396 NM_029935 NP_084211
|
| Function |
Sulfotransferase that transfers sulfate from 3'- phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non- reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B- cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=A small fraction may also be present at the cell surface, where it acts as a B-cell receptor.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
|
