| Gene Symbol | Chst15 |
|---|---|
| Entrez Gene | 77590 |
| Alt Symbol | 4631426J05Rik, BRAG, GalNAcS-6ST, MAd5, mKIAA0598 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 |
| Other Description | B-cell RAG-associated gene protein|GalNAc 4-sulfate 6-O-sulfotransferase|GalNAc4S-6ST|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase|carbohydrate sulfotransferase 15 |
| Swissprots | Q8BLQ5 Q80TW4 Q91XQ5 Q9D2N6 |
| Accessions | EDL17724 EDL17725 EDL17726 Q91XQ5 AB187269 BAD89559 AF320786 AAK69604 AK019474 BAB31743 AK031745 AK031995 AK035637 BAC29133 AK043803 BAC31658 AK082318 BAC38463 AK083614 BAC38968 AK122324 BAC65606 BC031443 AAH31443 XM_006508332 XP_006508395 XM_006508333 XP_006508396 NM_029935 NP_084211 |
| Function | Sulfotransferase that transfers sulfate from 3'- phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non- reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B- cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo (By similarity). {ECO:0000250}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=A small fraction may also be present at the cell surface, where it acts as a B-cell receptor. |
| Top Pathways | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate |
GalNAc4S-6ST CRISPR/Cas9 KO Plasmid (m) - sc-429546 from Santa Cruz Biotechnology
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GalNAc4S-6ST HDR Plasmid (m) - sc-429546-HDR from Santa Cruz Biotechnology
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GalNAc4S-6ST Double Nickase Plasmid (m) - sc-429546-NIC from Santa Cruz Biotechnology
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GalNAc4S-6ST Double Nickase Plasmid (m2) - sc-429546-NIC-2 from Santa Cruz Biotechnology
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GalNAc4S-6ST CRISPR Activation Plasmid (m) - sc-429546-ACT from Santa Cruz Biotechnology
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GalNAc4S-6ST CRISPR Activation Plasmid (m2) - sc-429546-ACT-2 from Santa Cruz Biotechnology
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GalNAc4S-6ST Lentiviral Activation Particles (m) - sc-429546-LAC from Santa Cruz Biotechnology
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GalNAc4S-6ST Lentiviral Activation Particles (m2) - sc-429546-LAC-2 from Santa Cruz Biotechnology
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GalNAc4S-6ST siRNA (m) - sc-145317 from Santa Cruz Biotechnology
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GalNAc4S-6ST shRNA Plasmid (m) - sc-145317-SH from Santa Cruz Biotechnology
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GalNAc4S-6ST shRNA (m) Lentiviral Particles - sc-145317-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU024131 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN28746 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND28746 from Sigma-Aldrich
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CHST15 siRNA (Mouse) - CRM9824 from Cohesion Biosciences
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CHST15 - MBS8228907 from MyBioSource
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shRNA set against Mouse CHST15 (NM_029935.5) - SHH263781 from Creative biogene
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shRNA set against Mouse 4631426J05Rik(NM_029935.5) - SHG012385 from Creative biogene
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CHST15 shRNA Plasmid (Mouse) - CHM9824 from Cohesion Biosciences
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CHST15 miRNA 3'UTR clone - MiUTR1M-00579 from Creative biogene
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