| Gene Symbol |
HIST1H1C
|
| Entrez Gene |
3006
|
| Alt Symbol |
H1.2, H1C, H1F2, H1s-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
histone cluster 1, H1c
|
| Other Description |
H1 histone family, member 2|histone 1, H1c|histone H1.2|histone H1c|histone H1d|histone H1s-1
|
| Swissprots |
A8K4I2 P16403
|
| Accessions |
AAN06700 CAA40408 EAW55515 P16403 AB451259 BAG70073 AB451385 BAG70199 AK290947 BAF83636 BC002649 D28457 BAA05823 EU446960 ABZ92489 EU832089 ACE87439 EU832181 ACE86751 NM_005319 NP_005310
|
| Function |
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus. Chromosome. Note=Mainly localizes in euchromatin. Distribution goes in parallel with DNA concentration.
|
![Western Blot: Histone H1.2 Overexpression Lysate (Adult Normal) [NBL1-11553] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Histone H1.2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9811_Histone%2520H1.2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11553-img0002.jpg)