Gene Symbol | GGA1 |
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Entrez Gene | 26088 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | golgi-associated, gamma adaptin ear containing, ARF binding protein 1 |
Other Description | ADP-ribosylation factor binding protein 1|ADP-ribosylation factor-binding protein GGA1|gamma-adaptin related protein 1|gamma-adaptin-related protein 1|golgi associated, gamma adaptin ear containing, ARF binding protein 1|golgi-localized, gamma ear-containing, ARF-binding protein 1 |
Swissprots | A8K3D3 B0QYR7 Q9UG00 Q9UGW1 Q6IC75 Q9UJY5 Q5R3N1 Q5TG07 Q9BW94 Q9UGW0 Q86YA9 Q8NCS6 |
Accessions | CAF86574 EAW60168 EAW60169 EAW60170 Q9UJY5 AF190862 AAF05707 AF218584 AAF42847 AF233521 AAF35393 AK075256 BAC11501 AK092417 AK095427 BAG53054 AK097270 AK122898 BAG53788 AK225157 AK290548 BAF83237 AL110219 CAB53679 BC000538 AAH00538 BC010917 AAH10917 BC029388 AAH29388 BC044629 AAH44629 CR456493 CAG30379 CU013090 CAK54521 CU013378 CAK54820 DA455573 DQ593821 XM_005261517 XP_005261574 XM_005261518 XP_005261575 XM_005261520 XP_005261577 XM_005261522 XP_005261579 XM_006724229 XP_006724292 XM_011530122 XP_011528424 XM_011530123 XP_011528425 XM_011530124 XP_011528426 XM_011530125 XP_011528427 NM_001001560 NP_001001560 NM_001172687 NP_001166158 NM_001172688 NP_001166159 NM_013365 NP_037497 NM_001001561 |
Function | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. {ECO:0000269|PubMed:11301005}. |
Subcellular Location | Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. |
Tissue Specificity | Ubiquitously expressed. |
Top Pathways | Lysosome |
GGA1 CRISPR/Cas9 KO Plasmid (h) - sc-416706 from Santa Cruz Biotechnology
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GGA1 HDR Plasmid (h) - sc-416706-HDR from Santa Cruz Biotechnology
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GGA1 Double Nickase Plasmid (h) - sc-416706-NIC from Santa Cruz Biotechnology
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GGA1 Double Nickase Plasmid (h2) - sc-416706-NIC-2 from Santa Cruz Biotechnology
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GGA1 CRISPR Activation Plasmid (h) - sc-416706-ACT from Santa Cruz Biotechnology
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GGA1 CRISPR Activation Plasmid (h2) - sc-416706-ACT-2 from Santa Cruz Biotechnology
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GGA1 Lentiviral Activation Particles (h) - sc-416706-LAC from Santa Cruz Biotechnology
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GGA1 Lentiviral Activation Particles (h2) - sc-416706-LAC-2 from Santa Cruz Biotechnology
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GGA1 siRNA (h) - sc-41167 from Santa Cruz Biotechnology
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GGA1 shRNA Plasmid (h) - sc-41167-SH from Santa Cruz Biotechnology
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GGA1 shRNA (h) Lentiviral Particles - sc-41167-V from Santa Cruz Biotechnology
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GGA1 RNAi - H00026088-R01V from Novus Biologicals
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GGA1 RNAi - H00026088-R01 from Novus Biologicals
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MISSION® esiRNA - EHU080091 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9252 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9252 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07852 from Sigma-Aldrich
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GGA1 siRNA (Human) - CRH8701 from Cohesion Biosciences
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GGA1 RNAi - H00026088-R02 from Novus Biologicals
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GGA1 RNAi - H00026088-R03 from Novus Biologicals
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GGA1 - MBS8207301 from MyBioSource
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shRNA set against Human GGA1 (NM_013365.4) - SHH300734 from Creative biogene
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Human GGA1 siRNA - orb269203 from Biorbyt
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GGA1 shRNA Plasmid (Human) - CHH8701 from Cohesion Biosciences
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GGA1 miRNA 3'UTR clone - MiUTR3H-08126 from Creative biogene
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