Gene Symbol | TRPC1 |
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Entrez Gene | 7220 |
Alt Symbol | HTRP-1, TRP1 |
Species | Human |
Gene Type | protein-coding |
Description | transient receptor potential cation channel, subfamily C, member 1 |
Other Description | TRP-1|capacitative calcium channel protein Trp1|short transient receptor potential channel 1|transient receptor potential canonical 1|transient receptor protein 1 |
Swissprots | Q14CE4 P48995 |
Accessions | CAJ01296 EAW78963 EAW78964 P48995 AB255425 BAF76425 AF483645 AAM97860 AI280444 BC112338 AAI12339 BC113953 AAI13954 BX331349 DB185459 EF522961 ABP94017 GQ293239 ACT66710 X89066 CAA61447 XM_005247738 XP_005247795 XM_005247739 XP_005247796 XR_241506 XR_924164 XR_924165 XR_924166 NM_001251845 NP_001238774 NM_003304 NP_003295 |
Function | Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. {ECO:0000269|PubMed:15016832}. |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Tissue Specificity | Seems to be ubiquitous. |
Top Pathways | Pancreatic secretion, Glutamatergic synapse |
TRPC1 CRISPR/Cas9 KO Plasmid (h) - sc-401040 from Santa Cruz Biotechnology
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TRPC1 HDR Plasmid (h) - sc-401040-HDR from Santa Cruz Biotechnology
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TRPC1 Double Nickase Plasmid (h) - sc-401040-NIC from Santa Cruz Biotechnology
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TRPC1 Double Nickase Plasmid (h2) - sc-401040-NIC-2 from Santa Cruz Biotechnology
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TRPC1 CRISPR Activation Plasmid (h) - sc-401040-ACT from Santa Cruz Biotechnology
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TRPC1 CRISPR Activation Plasmid (h2) - sc-401040-ACT-2 from Santa Cruz Biotechnology
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TRPC1 Lentiviral Activation Particles (h) - sc-401040-LAC from Santa Cruz Biotechnology
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TRPC1 Lentiviral Activation Particles (h2) - sc-401040-LAC-2 from Santa Cruz Biotechnology
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TRPC1 siRNA (h) - sc-42664 from Santa Cruz Biotechnology
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TRPC1 shRNA Plasmid (h) - sc-42664-SH from Santa Cruz Biotechnology
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TRPC1 shRNA (h) Lentiviral Particles - sc-42664-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU070211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22052 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22052 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10274 from Sigma-Aldrich
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TRPC1 siRNA (Human) - CRH4945 from Cohesion Biosciences
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TRP1 RNAi - H00007220-R01 from Novus Biologicals
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TRPC1 - MBS8213883 from MyBioSource
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shRNA set against Human TRPC1 (NM_003304.4) - SHH435524 from Creative biogene
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shRNA set against Human TRPC1(NM_003304.4) - SHL096672 from Creative biogene
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Human TRPC1 siRNA - orb265447 from Biorbyt
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TRPC1 shRNA Plasmid (Human) - CHH4945 from Cohesion Biosciences
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TRPC1 miRNA 3'UTR clone - MiUTR1H-10780 from Creative biogene
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