| Gene Symbol | HSD11B2 |
|---|---|
| Entrez Gene | 3291 |
| Alt Symbol | AME, AME1, HSD11K, HSD2, SDR9C3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | hydroxysteroid (11-beta) dehydrogenase 2 |
| Other Description | -HSD11 type II|11-DH2|11-beta-HSD2|11-beta-hydroxysteroid dehydrogenase type 2|11-beta-hydroxysteroid dehydrogenase type II|NAD-dependent 11-beta-hydroxysteroid dehydrogenase|corticosteroid 11-beta-dehydrogenase isozyme 2|short chain dehydrogenase/reductase family 9C member 3 |
| Swissprots | Q9UCW8 Q9UC50 Q8N439 Q9UCW6 A7LB28 P80365 Q9UCW5 C5HTY7 Q9UCW7 Q13194 Q96QN8 Q9UC51 Q6P2G9 |
| Accessions | AAB48544 AAD14324 AAK91586 ABS29267 ACS13714 EAW83134 P80365 BC036780 AAH36780 BC064536 AAH64536 U14631 AAA91969 U26726 AAC50356 NM_000196 NP_000187 |
| Function | Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. |
| Subcellular Location | Microsome {ECO:0000269|PubMed:17314322}. Endoplasmic reticulum {ECO:0000269|PubMed:17314322}. |
| Tissue Specificity | Found in placenta, kidney, pancreas, prostate, ovary, small intestine and colon. |
| Top Pathways | Steroid hormone biosynthesis, Aldosterone-regulated sodium reabsorption |