| Gene Symbol |
HSD11B2
|
| Entrez Gene |
3291
|
| Alt Symbol |
AME, AME1, HSD11K, HSD2, SDR9C3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hydroxysteroid (11-beta) dehydrogenase 2
|
| Other Description |
-HSD11 type II|11-DH2|11-beta-HSD2|11-beta-hydroxysteroid dehydrogenase type 2|11-beta-hydroxysteroid dehydrogenase type II|NAD-dependent 11-beta-hydroxysteroid dehydrogenase|corticosteroid 11-beta-dehydrogenase isozyme 2|short chain dehydrogenase/reductase family 9C member 3
|
| Swissprots |
Q9UCW8 Q9UC50 Q8N439 Q9UCW6 A7LB28 P80365 Q9UCW5 C5HTY7 Q9UCW7 Q13194 Q96QN8 Q9UC51 Q6P2G9
|
| Accessions |
AAB48544 AAD14324 AAK91586 ABS29267 ACS13714 EAW83134 P80365 BC036780 AAH36780 BC064536 AAH64536 U14631 AAA91969 U26726 AAC50356 NM_000196 NP_000187
|
| Function |
Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
|
| Subcellular Location |
Microsome {ECO:0000269|PubMed:17314322}. Endoplasmic reticulum {ECO:0000269|PubMed:17314322}.
|
| Tissue Specificity |
Found in placenta, kidney, pancreas, prostate, ovary, small intestine and colon.
|
| Top Pathways |
Steroid hormone biosynthesis, Aldosterone-regulated sodium reabsorption
|
![Western Blot: HSD11B2 Overexpression Lysate (Adult Normal) [NBL1-11721] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HSD11B2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8366_HSD11B2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11721-img0002.jpg)