CTSC

Gene Symbol CTSC
Entrez Gene 1075
Alt Symbol CPPI, DPP-I, DPP1, DPPI, HMS, JP, JPD, PALS, PDON1, PLS
Species Human
Gene Type protein-coding
Description cathepsin C
Other Description cathepsin J|dipeptidyl peptidase 1|dipeptidyl peptidase I|dipeptidyl transferase|dipeptidyl-peptidase I
Swissprots P53634 Q71E76 Q8WYA7 Q2HIY8 Q7Z3G7 Q8WY99 Q8WYA8 A8K7V2 Q7M4N9 Q53G93 Q7Z5U7 Q71E75 B5MDD5
Accessions AAC51341 AFK75976 AFK75977 AFK75978 AFK75979 AFK75980 AFK75981 AFK75982 AFK75983 AFK75984 AFK75985 AFK75986 AFK75987 AFK75988 AFK75989 AFK75990 AFK75991 AFK75992 AFK75993 AFK75994 AFK75995 AFK75996 AFK75997 AFK75998 AFK75999 AFK76000 AFK76001 AFK76002 AFK76003 AFK76004 AFK76005 AFK76006 AFK76007 AFK76008 AFK76009 AFK76010 AFK76011 AFK76012 AFK76013 AFK76014 AFK76015 AFK76016 AFK76017 AFK76018 AFK76019 AFK76020 AFK76021 AFK76022 AFK76023 AFK76024 AFK76025 AFK76026 AFK76027 AFK76028 AFK76029 EAW59363 EAW59364 P53634 AA011305 AF234263 AAL48191 AF234264 AAL48192 AF254757 AAL48195 AF525032 AAQ08887 AF525033 AAQ08888 AI821972 AK223038 BAD96758 AK292117 BAF84806 AK296190 BAG58920 AK311923 BAG34864 AM393622 CAL38498 AU076460 BC023559 BC054028 AAH54028 BC100891 AAI00892 BC100892 AAI00893 BC100893 AAI00894 BC100894 AAI00895 BC107770 BC109386 AAI09387 BC110071 AAI10072 BC113850 AAI13851 BC113897 AAI13898 BC146692 AAI46693 BM997817 BX459226 BX537913 CAD97897 CB114425 CN368896 X87212 CAA60671 NM_001114173 NP_001107645 NM_001814 NP_001805 NM_148170 NP_680475
Function Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII. {ECO:0000269|PubMed:1586157}.
Subcellular Location Lysosome.
Tissue Specificity Ubiquitous. Highly expressed in lung, kidney and placenta. Detected at intermediate levels in colon, small intestine, spleen and pancreas. {ECO:0000269|PubMed:9092576}.
Top Pathways Lysosome

cathepsin C (D-6) - sc-74590 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cathepsin C (D-6): sc-74590. Western blot analysis of cathepsin C expression in M1 (A) and HISM (B) whole cell lysates.

cathepsin C (H-144) - sc-13986 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
cathepsin C (H-144): sc-13986. Western blot analysis of cathepsin C expression in M1 whole cell lysate.

cathepsin C (L-14) - sc-5646 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
cathepsin C (L-14): sc-5646. Immunoperoxidase staining of formalin fixed, paraffin-embedded human breast tumor showing cytoplasmic localization.

cathepsin C (T-17) - sc-5647 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
cathepsin C (T-17): sc-5647. Western blot analysis of cathepsin C expression in rat placenta tissue extract.

Anti-DPP1 antibody - ab178761 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-DPP1 antibody (ab178761) at 1 µg/ml + HTC15 whole cell lysate at 10 µg

Anti-DPP1 antibody - ab167322 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-DPP1 antibody (ab167322) at 1 µg/mlLane 1 : DPP1-transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.

Anti-DPP1 antibody [EPR7749] - C-terminal - ab192019 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7749
All lanes : Anti-DPP1 antibody [EPR7749] - C-terminal (ab192019) at 1/1000 dilutionLane 1 : HT29 cell lysatesLane 2 : JAR cell lysatesLane 3 : A549 cell lysatesLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilutiondeveloped using the ECL technique

Anti-DPP1 antibody - C-terminal - ab199109 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-DPP1 antibody - C-terminal (ab199109) at 1/1000 dilution + Human placenta tissue lysate at 40 µg

Anti-DPP1 antibody - Catalytic domain - ab49233 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DPP1 antibody - Catalytic domain (ab49233) at 1/1000 dilutionLane 1 : Recombinant Human DPP-1 at 0.04 µgLane 2 : Recombinant Human DPP-1 at 0.02 µgLane 3 : Recombinant Human DPP-1 at 0.01 µgLane 4 : Recombinant Human DPP-1 at 0.004 µgLane 5 : Recombinant Human DPP-1 at 0.002 µg

Anti-DPP1 antibody - Propeptide domain - ab49227 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DPP1 antibody - Propeptide domain (ab49227) at 1/1000 dilutionLane 1 : Recombinant Human DPP-1 at 0.04 µgLane 2 : Recombinant Human DPP-1 at 0.02 µgLane 3 : Recombinant Human DPP-1 at 0.01 µgLane 4 : Recombinant Human DPP-1 at 0.004 µgLane 5 : Recombinant Human DPP-1 at 0.002 µg

Anti-CTSC / Cathepsin C / JP Antibody - LS-C147355 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTSC / Cathepsin C / JP Antibody (Biotin) - LS-C147356 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTSC / Cathepsin C / JP Antibody - LS-C147357 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTSC / Cathepsin C / JP Antibody (aa231-463, Biotin) - LS-C300442 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTSC / Cathepsin C / JP Antibody (aa345-394) - LS-C121074 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of extracts from Jurkat cells, treated with etoposide 25 uM 1h, using Dipeptidyl-peptidase 1 (heavy chain, Cleaved-Arg394) Antibody. The lane on the right is treated with the synthesized peptide.

Anti-CTSC / Cathepsin C / JP Antibody (aa231-462, FITC) - LS-C303397 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTSC / Cathepsin C / JP Antibody (aa231-462, Biotin) - LS-C301294 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTSC / Cathepsin C / JP Antibody (aa185-234) - LS-C135714 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CTSC / Cathepsin C antibody LS-C135714 Western blot of PANC1 cell lysate.

Anti-CTSC / Cathepsin C / JP Antibody (aa231-462) - LS-C293247 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of recombinant CTSC / Cathepsin C / JP.

Anti-CTSC / Cathepsin C / JP Antibody (aa151-200) - LS-C187240 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of Human HCT15. CTSC antibody dilution 1.0 ug/ml.

Anti-CTSC / Cathepsin C / JP Antibody (aa231-463, FITC) - LS-C303830 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTSC / Cathepsin C / JP Antibody (aa231-463) - LS-C293246 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of recombinant CTSC / Cathepsin C / JP.

Anti-CTSC / Cathepsin C / JP Antibody - LS-C306747 from LifeSpan Bioscience

Host Mouse
Clonality Polyclonal

Anti-CTSC / Cathepsin C / JP Antibody - LS-C309728 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTSC / Cathepsin C / JP Antibody (aa238-252) IHC-plus™ - LS-B10387 from LifeSpan Bioscience

Host Goat
Clonality Polyclonal
Anti-CTSC / Cathepsin C / JP antibody IHC staining of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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