| Gene Symbol |
NUPR1
|
| Entrez Gene |
26471
|
| Alt Symbol |
COM1, P8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear protein, transcriptional regulator, 1
|
| Other Description |
candidate of metastasis 1|nuclear protein 1|protein p8
|
| Swissprots |
O60357 B2R5C4 Q6FGG3 O60356
|
| Accessions |
AAC05335 AAC05336 AAC19385 EAW52274 EAW52275 EAW52276 O60356 AF069073 AAC19384 AF135266 AAD49221 AK312135 BAG35071 BC002434 AAH02434 BF965595 BP214401 BT006896 AAP35542 CR542144 CAG46941 NM_001042483 NP_001035948 NM_012385 NP_036517
|
| Function |
Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 'Lys-16' acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin. {ECO:0000269|PubMed:19650074, ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:22858377}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10092851}.
|
| Tissue Specificity |
Widely expressed, with high levels in liver, pancreas, prostate, ovary, colon, thyroid, spinal cord, trachea and adrenal gland, moderate levels in heart, placenta, lung, skeletal muscle, kidney, testis, small intestine, stomach and lymph node, and low levels in brain, spleen, thymus and bone marrow. Not detected in peripheral blood leukocytes. {ECO:0000269|PubMed:10092851}.
|
| Top Pathways |
Transcriptional misregulation in cancer
|