NUPR1

Gene Symbol	NUPR1
Entrez Gene	26471
Alt Symbol	COM1, P8
Species	Human
Gene Type	protein-coding
Description	nuclear protein, transcriptional regulator, 1
Other Description	candidate of metastasis 1|nuclear protein 1|protein p8
Swissprots	O60357 B2R5C4 Q6FGG3 O60356
Accessions	AAC05335 AAC05336 AAC19385 EAW52274 EAW52275 EAW52276 O60356 AF069073 AAC19384 AF135266 AAD49221 AK312135 BAG35071 BC002434 AAH02434 BF965595 BP214401 BT006896 AAP35542 CR542144 CAG46941 NM_001042483 NP_001035948 NM_012385 NP_036517
Function	Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 'Lys-16' acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin. {ECO:0000269|PubMed:19650074, ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:22858377}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:10092851}.
Tissue Specificity	Widely expressed, with high levels in liver, pancreas, prostate, ovary, colon, thyroid, spinal cord, trachea and adrenal gland, moderate levels in heart, placenta, lung, skeletal muscle, kidney, testis, small intestine, stomach and lymph node, and low levels in brain, spleen, thymus and bone marrow. Not detected in peripheral blood leukocytes. {ECO:0000269|PubMed:10092851}.
Top Pathways	Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human p8 full length protein - ab161980 from Abcam Category Protein Source Wheat germ Species Human

Human p8 peptide - ab45567 from Abcam Category Peptide Species Human

NUPR1 Antibody Blocking Peptide - LS-E25685 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NUPR1 Antibody Blocking Peptide - LS-E23421 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human COM1/p8 Protein - H00026471-P01 from Novus Biologicals Category Protein Prices $305.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

P8 blocking peptide - GTX26052-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

p8 Peptide - AC21-0515-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

NUPR1 / COM1 - H00026471-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

NUPR1 Peptide - 45-987P from ProSci Category Peptide

NUPR1 fusion protein - Ag7092 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

NUPR1 fusion protein - Ag7039 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human NUPR1, His-tagged - NUPR1-1423H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Nuclear protein 1(NUPR1) - CSB-YP527662HU CSB-EP527662HU CSB-BP527662HU CSB-MP527662HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

NUPR1 / COM1 (transcript variant 2) - TP300585 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

P8/NUPR1, Peptide - MBS425423 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

NUPR1 Peptide, Human - M34GP10753H from Creative Peptides Category Peptide Source Synthetic. Species Human

COM1/p8 Recombinant Protein Antigen - NBP2-56142PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Nuclear protein 1 (NUPR1), Recombinant Protein - MBS1079815 from MyBioSource Category Protein Prices $810.00, $810.00, $1,035.00, $1,035.00, $1,150.00, $1,150.00, $1,605.00, $1,605.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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