| Gene Symbol |
DGKH
|
| Entrez Gene |
160851
|
| Alt Symbol |
DGKeta
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
diacylglycerol kinase, eta
|
| Other Description |
DAG kinase eta|diacylglycerol kinase eta|diglyceride kinase eta
|
| Swissprots |
Q8N3N0 Q86XP2 A2A2W7 Q86XP1 Q8N7J9 A6NFX7 Q5VZW0 B4DZ34 Q6PI56
|
| Accessions |
EAX08671 EAX08672 EAX08673 EAX08674 EAX08675 Q86XP1 AB078967 BAC66960 AB078968 BAC66961 AI675047 AK054970 AK055427 AK090591 AK098302 BAC05280 AK122909 AK130015 AK289546 BAF82235 AK302631 BAG63873 AK302727 BAG63946 AL833883 CAD38739 BC043292 AAH43292 BC044822 BM978856 DR002010 NM_001204504 NP_001191433 NM_001204505 NP_001191434 NM_001204506 NP_001191435 NM_001297429 NP_001284358 NM_152910 NP_690874 NM_178009 NP_821077 NR_123714 NR_123715
|
| Function |
Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization. {ECO:0000269|PubMed:12810723, ECO:0000269|PubMed:19710016}.
|
| Subcellular Location |
Cytoplasm. Cell membrane. Note=Translocated from the cytoplasm to endosomes in response to stress stimuli. Isoform 2 is rapidly relocated back to the cytoplasm upon removal of stress stimuli, whereas isoform 1 exhibits sustained endosomal association. Translocates from the cytoplasm to the cell membrane in the presence of active GTP-bound form of HRAS.
|
| Tissue Specificity |
Isoform 2 is ubiquitously expressed. Isoform 1 is expressed only in testis, kidney and colon. {ECO:0000269|PubMed:12810723}.
|
| Top Pathways |
Choline metabolism in cancer, Glycerolipid metabolism, Glycerophospholipid metabolism, Phosphatidylinositol signaling system
|