DGKH

Gene Symbol DGKH
Entrez Gene 160851
Alt Symbol DGKeta
Species Human
Gene Type protein-coding
Description diacylglycerol kinase, eta
Other Description DAG kinase eta|diacylglycerol kinase eta|diglyceride kinase eta
Swissprots Q8N3N0 Q86XP2 A2A2W7 Q86XP1 Q8N7J9 A6NFX7 Q5VZW0 B4DZ34 Q6PI56
Accessions EAX08671 EAX08672 EAX08673 EAX08674 EAX08675 Q86XP1 AB078967 BAC66960 AB078968 BAC66961 AI675047 AK054970 AK055427 AK090591 AK098302 BAC05280 AK122909 AK130015 AK289546 BAF82235 AK302631 BAG63873 AK302727 BAG63946 AL833883 CAD38739 BC043292 AAH43292 BC044822 BM978856 DR002010 NM_001204504 NP_001191433 NM_001204505 NP_001191434 NM_001204506 NP_001191435 NM_001297429 NP_001284358 NM_152910 NP_690874 NM_178009 NP_821077 NR_123714 NR_123715
Function Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization. {ECO:0000269|PubMed:12810723, ECO:0000269|PubMed:19710016}.
Subcellular Location Cytoplasm. Cell membrane. Note=Translocated from the cytoplasm to endosomes in response to stress stimuli. Isoform 2 is rapidly relocated back to the cytoplasm upon removal of stress stimuli, whereas isoform 1 exhibits sustained endosomal association. Translocates from the cytoplasm to the cell membrane in the presence of active GTP-bound form of HRAS.
Tissue Specificity Isoform 2 is ubiquitously expressed. Isoform 1 is expressed only in testis, kidney and colon. {ECO:0000269|PubMed:12810723}.
Top Pathways Choline metabolism in cancer, Glycerolipid metabolism, Glycerophospholipid metabolism, Phosphatidylinositol signaling system

Anti-DGKH antibody - ab80693 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample Type : Adult mouse cortex. Primary Antibody Dilution : 1:500. Secondary Antibody : Anti-rabbit-Cy3. Secondary Antibody Dilution : 1:1000. Color/Signal Descriptions : Red: DGKH Cyan: Nissl (Neurons). Gene Name : DGKH.

Anti-DGKH antibody - ab196679 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human colon carcinoma tissue labeling DGKH with ab196679 at 1/50 dilution, in the presence (right panel) or absence (left panel) of immunizing peptide.

Anti-DGKH antibody - ab58047 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab58047 DGKH antibody at 1ug/ml.

Anti-DGKeta / DGKH Antibody (aa831-930) - LS-C307232 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-DGKeta / DGKH Antibody (aa771-820) - LS-C119127 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human colon carcinoma tissue, using DGKH Antibody. The picture on the right is treated with the synthesized peptide.

Anti-DGKeta / DGKH Antibody (aa758-807) - LS-C80763 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal heart lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 6-18%.

Anti-DGKeta / DGKH Antibody (aa648-697) - LS-C111062 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
DGKH antibody LS-C111062 Western blot of Fetal Liver lysate.

DGKH Antibody - NBP1-85228 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DGKH Antibody - NBP1-85229 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DGKH antibody produced in rabbit - SAB4500616 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-DGKH: <B>Cat. No. SAB4500616</B>: Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using Anti-DGKH antibody. Cells on the left were treated with the Anti-DGKH antibody. Cells on the right (negative control) were treated with both Anti-DGKH antibody and the synthesized immunogen peptide.

Anti-DGKH (ab2) antibody produced in rabbit - SAB2100570 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-DGKH (ab2): <B>Cat. No.SAB2100570</B>: DGKH in Fetal Liver tissue lysate with DGKH antibody at 1.0 μg/mL.

Anti-DGKH antibody produced in rabbit - HPA040355 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-DGKH: <B>Cat. No. HPA040355</B>: Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in tubular cells.

Monoclonal Anti-DGKH antibody produced in mouse - WH0160851M1 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2G11
<B>Immunoblotting</B><BR/>Monoclonal Anti-DGKH, <B>Cat. No. WH0160851M1</B> used at the antibody concentration: 1 μg/mL. Specific band of ~37 kDa using immunogen protein lysate.

Anti-DGKH (ab1) antibody produced in rabbit - SAB2100569 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-DGKH (ab1): <B>Cat. No.SAB2100569</B>: DGKH in Fetal Heart tissue lysate with DGKH antibody at 1.0 μg/mL.

DGKH antibody - middle region (ARP45738_P050) - ARP45738_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DGKH antibody - middle region (ARP45739_P050) - ARP45739_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DGKH Antibody (OAAF02526) - OAAF02526 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

DGKH antibody - 70R-16812 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti -DGKH (Diacylglycerol Kinase eta, DAG Kinase eta, Diglyceride Kinase eta, DGK-eta,DKFZp761I1510) - 125801 from USBiological Life Science

Host Mouse
Clonality Monoclonal
Clone 2G11

DGKH antibody - 70R-5760 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
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