| Gene Symbol | Kirrel |
|---|---|
| Entrez Gene | 170643 |
| Alt Symbol | 6720469N11Rik, Kirrel1, Neph1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | kin of IRRE like (Drosophila) |
| Other Description | kin of IRRE like 1|kin of IRRE-like protein 1|kin of irregular chiasm-like protein 1|nephrin 1|nephrin-like protein 1 |
| Swissprots | Q8CJ59 Q80W68 Q923L4 Q8CIJ4 |
| Accessions | EDL15364 EDL15365 Q80W68 AF480411 AAN73043 AI843542 AK032898 AK034569 AK158381 AK209127 AY017368 AAK00528 AY243095 AAO91769 BC023765 AAH23765 BC062651 BY736743 CJ106213 CJ128949 CV559096 XM_006501076 XP_006501139 XM_011240028 XP_011238330 XM_011240029 XP_011238331 NM_001170985 NP_001164456 NM_130867 NP_570937 |
| Function | Plays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. {ECO:0000269|PubMed:11416156}. |
| Subcellular Location | Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Predominantly located at podocyte slit diaphragm. |
| Tissue Specificity | Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli. {ECO:0000269|PubMed:12865409}. |