| Gene Symbol |
Kirrel
|
| Entrez Gene |
170643
|
| Alt Symbol |
6720469N11Rik, Kirrel1, Neph1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
kin of IRRE like (Drosophila)
|
| Other Description |
kin of IRRE like 1|kin of IRRE-like protein 1|kin of irregular chiasm-like protein 1|nephrin 1|nephrin-like protein 1
|
| Swissprots |
Q8CJ59 Q80W68 Q923L4 Q8CIJ4
|
| Accessions |
EDL15364 EDL15365 Q80W68 AF480411 AAN73043 AI843542 AK032898 AK034569 AK158381 AK209127 AY017368 AAK00528 AY243095 AAO91769 BC023765 AAH23765 BC062651 BY736743 CJ106213 CJ128949 CV559096 XM_006501076 XP_006501139 XM_011240028 XP_011238330 XM_011240029 XP_011238331 NM_001170985 NP_001164456 NM_130867 NP_570937
|
| Function |
Plays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. {ECO:0000269|PubMed:11416156}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Predominantly located at podocyte slit diaphragm.
|
| Tissue Specificity |
Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli. {ECO:0000269|PubMed:12865409}.
|