Gene Symbol | Kirrel |
---|---|
Entrez Gene | 170643 |
Alt Symbol | 6720469N11Rik, Kirrel1, Neph1 |
Species | Mouse |
Gene Type | protein-coding |
Description | kin of IRRE like (Drosophila) |
Other Description | kin of IRRE like 1|kin of IRRE-like protein 1|kin of irregular chiasm-like protein 1|nephrin 1|nephrin-like protein 1 |
Swissprots | Q8CJ59 Q80W68 Q923L4 Q8CIJ4 |
Accessions | EDL15364 EDL15365 Q80W68 AF480411 AAN73043 AI843542 AK032898 AK034569 AK158381 AK209127 AY017368 AAK00528 AY243095 AAO91769 BC023765 AAH23765 BC062651 BY736743 CJ106213 CJ128949 CV559096 XM_006501076 XP_006501139 XM_011240028 XP_011238330 XM_011240029 XP_011238331 NM_001170985 NP_001164456 NM_130867 NP_570937 |
Function | Plays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. {ECO:0000269|PubMed:11416156}. |
Subcellular Location | Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Predominantly located at podocyte slit diaphragm. |
Tissue Specificity | Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli. {ECO:0000269|PubMed:12865409}. |
NEPH1 CRISPR/Cas9 KO Plasmid (m) - sc-431274 from Santa Cruz Biotechnology
|
||||||||
NEPH1 HDR Plasmid (m) - sc-431274-HDR from Santa Cruz Biotechnology
|
||||||||
NEPH1 Double Nickase Plasmid (m) - sc-431274-NIC from Santa Cruz Biotechnology
|
||||||||
NEPH1 Double Nickase Plasmid (m2) - sc-431274-NIC-2 from Santa Cruz Biotechnology
|
||||||||
NEPH1 CRISPR Activation Plasmid (m) - sc-431274-ACT from Santa Cruz Biotechnology
|
||||||||
NEPH1 CRISPR Activation Plasmid (m2) - sc-431274-ACT-2 from Santa Cruz Biotechnology
|
||||||||
NEPH1 Lentiviral Activation Particles (m) - sc-431274-LAC from Santa Cruz Biotechnology
|
||||||||
NEPH1 Lentiviral Activation Particles (m2) - sc-431274-LAC-2 from Santa Cruz Biotechnology
|
||||||||
NEPH1 siRNA (m) - sc-44770 from Santa Cruz Biotechnology
|
||||||||
NEPH1 shRNA Plasmid (m) - sc-44770-SH from Santa Cruz Biotechnology
|
||||||||
NEPH1 shRNA (m) Lentiviral Particles - sc-44770-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EMU086591 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN34307 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND34307 from Sigma-Aldrich
|
||||||||
KIRREL siRNA (Mouse) - CRN1328 from Cohesion Biosciences
|
||||||||
shRNA set against Mouse KIRREL (NM_130867.3) - SHH325551 from Creative biogene
|
||||||||
Mouse KIRREL siRNA - orb290803 from Biorbyt
|
||||||||
KIRREL shRNA Plasmid (Mouse) - CHN1328 from Cohesion Biosciences
|
||||||||