Gene Symbol | NXT1 |
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Entrez Gene | 29107 |
Alt Symbol | MTR2, P15 |
Species | Human |
Gene Type | protein-coding |
Description | nuclear transport factor 2-like export factor 1 |
Other Description | NTF2-like export factor 1|NTF2-related export protein 1|NTX2-like export factor1|NUTF-like export factor 1|protein p15 |
Swissprots | Q9UKK6 |
Accessions | EAX10163 Q9UKK6 AF156957 AAD54942 AK026360 BC000759 AAH00759 BC002687 AAH02687 BC003029 AAH03029 BC003410 AAH03410 XM_011529230 XP_011527532 NM_013248 NP_037380 |
Function | Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5. {ECO:0000269|PubMed:10567585, ECO:0000269|PubMed:10848583, ECO:0000269|PubMed:11259602, ECO:0000269|PubMed:19165146}. |
Subcellular Location | Nucleus. Nucleus speckle {ECO:0000305}. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. |
Top Pathways | RNA transport, mRNA surveillance pathway, Ribosome biogenesis in eukaryotes, Influenza A |
NXT-1 CRISPR/Cas9 KO Plasmid (h) - sc-416906 from Santa Cruz Biotechnology
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NXT-1 HDR Plasmid (h) - sc-416906-HDR from Santa Cruz Biotechnology
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NXT-1 Double Nickase Plasmid (h) - sc-416906-NIC from Santa Cruz Biotechnology
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NXT-1 Double Nickase Plasmid (h2) - sc-416906-NIC-2 from Santa Cruz Biotechnology
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NXT-1 CRISPR Activation Plasmid (h) - sc-416906-ACT from Santa Cruz Biotechnology
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NXT-1 CRISPR Activation Plasmid (h2) - sc-416906-ACT-2 from Santa Cruz Biotechnology
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NXT-1 Lentiviral Activation Particles (h) - sc-416906-LAC from Santa Cruz Biotechnology
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NXT-1 Lentiviral Activation Particles (h2) - sc-416906-LAC-2 from Santa Cruz Biotechnology
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NXT-1 siRNA (h) - sc-41271 from Santa Cruz Biotechnology
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NXT-1 shRNA Plasmid (h) - sc-41271-SH from Santa Cruz Biotechnology
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NXT-1 shRNA (h) Lentiviral Particles - sc-41271-V from Santa Cruz Biotechnology
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NXT1 RNAi - H00029107-R01V from Novus Biologicals
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NXT1 RNAi - H00029107-R01 from Novus Biologicals
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MISSION® esiRNA - EHU111031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15658 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15658 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02284 from Sigma-Aldrich
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NXT1 siRNA (Human) - CRH9198 from Cohesion Biosciences
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shRNA set against Human NXT1 (NM_013248.2) - SHH356836 from Creative biogene
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shRNA set against Human NXT1(NM_013248.2) - SHR028444 from Creative biogene
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NXT1 shRNA Plasmid (Human) - CHH9198 from Cohesion Biosciences
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NXT1 miRNA 3'UTR clone - MiUTR1H-07009 from Creative biogene
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