PPP3CA
| Gene Symbol | PPP3CA |
|---|---|
| Entrez Gene | 5530 |
| Alt Symbol | CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein phosphatase 3, catalytic subunit, alpha isozyme |
| Other Description | CAM-PRP catalytic subunit|calcineurin A alpha|calmodulin-dependent calcineurin A subunit alpha isoform|protein phosphatase 2B, catalytic subunit, alpha isoform|protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform|serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform |
| Swissprots | A1A441 A8W6Z8 B5BUA2 A8W6Z7 A8K3B7 Q8TAW9 Q08209 |
| Accessions | EAX06123 EAX06124 EAX06125 Q08209 AB451338 BAG70152 AB451487 BAG70301 AK290532 BAF83221 AL353950 CAB89253 AM393486 CAL38363 AM393713 CAL38589 AW973358 AY904364 AAY17314 BC025714 AAH25714 BC098424 EU192652 ABW74484 EU192653 ABW74485 J05480 AAA35634 L14778 AAA02631 NM_000944 NP_000935 NM_001130691 NP_001124163 NM_001130692 NP_001124164 |
| Function | Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1. {ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:18838687}. |
| Subcellular Location | Cell membrane {ECO:0000250}. Cell membrane, sarcolemma {ECO:0000250}. Nucleus {ECO:0000250}. Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle. {ECO:0000250}. |
| Top Pathways | Glucagon signaling pathway, Glutamatergic synapse, Dopaminergic synapse, Amphetamine addiction, Oxytocin signaling pathway |
PP2B-Aα CRISPR/Cas9 KO Plasmid (h) - sc-401810 from Santa Cruz Biotechnology
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PP2B-Aα HDR Plasmid (h) - sc-401810-HDR from Santa Cruz Biotechnology
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PP2B-Aα Double Nickase Plasmid (h) - sc-401810-NIC from Santa Cruz Biotechnology
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PP2B-Aα Double Nickase Plasmid (h2) - sc-401810-NIC-2 from Santa Cruz Biotechnology
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PP2B-Aα CRISPR Activation Plasmid (h) - sc-401810-ACT from Santa Cruz Biotechnology
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PP2B-Aα CRISPR Activation Plasmid (h2) - sc-401810-ACT-2 from Santa Cruz Biotechnology
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PP2B-Aα Lentiviral Activation Particles (h) - sc-401810-LAC from Santa Cruz Biotechnology
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PP2B-Aα Lentiviral Activation Particles (h2) - sc-401810-LAC-2 from Santa Cruz Biotechnology
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PP2B-Aα siRNA (h) - sc-36304 from Santa Cruz Biotechnology
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PP2B-Aα shRNA Plasmid (h) - sc-36304-SH from Santa Cruz Biotechnology
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PP2B-Aα shRNA (h) Lentiviral Particles - sc-36304-V from Santa Cruz Biotechnology
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Calcineurin A RNAi - H00005530-R02 from Novus Biologicals
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MISSION® esiRNA - EHU017161 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0649 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0650 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0651 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17304 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17304 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11409 from Sigma-Aldrich
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PPP3CA siRNA (Human) - CRH3709 from Cohesion Biosciences
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shRNA set against Human PPP3CA (NM_000944.4) - SHH381532 from Creative biogene
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Human PPP3CA siRNA - orb264211 from Biorbyt
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PPP3CA shRNA Plasmid (Human) - CHH3709 from Cohesion Biosciences
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PPP3CA miRNA 3'UTR clone - MiUTR4H-TG06974 from Creative biogene
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