PITX3

Gene Symbol PITX3
Entrez Gene 5309
Alt Symbol ASMD, ASOD, CTPP4, CTRCT11, PTX3
Species Human
Gene Type protein-coding
Description paired-like homeodomain 3
Other Description homeobox protein PITX3|pituitary homeobox 3
Swissprots Q5VZL2 O75364
Accessions AJF45881 AJF45882 AJF45883 AJF45884 AJF45885 AJF45886 AJF45887 AJF45888 AJF45889 AJF45890 AJF45891 AJF45892 AJF45893 AJF45894 AJF45895 AJF45896 AJF45897 AJF45898 AJP06693 AJP06694 AJP06695 AJP06696 AJP06697 AJP06698 AJP06699 AJP06700 EAW49709 EAW49710 O75364 AF041339 AAC24502 BC011642 AAH11642 DQ891945 ABM82871 DQ895131 ABM86057 DQ895132 ABM86058 XM_011539865 XP_011538167 NM_005029 NP_005020
Function Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1- mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior len
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138}.
Tissue Specificity Highly expressed in developing eye lens.

Pitx3 (E-20) - sc-19308 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Pitx3 (E-20): sc-19308. Western blot analysis of Pitx3 expression in non-transfected: sc-117752 (A) and human Pitx3 transfected: sc-173175 (B) 293T whole cell lysates.

Pitx3 (N-20) - sc-19307 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Pitx3 (N-20): sc-19307. Western blot analysis of Pitx3 expression in non-transfected: sc-117752 (A) and human Pitx3 transfected: sc-173175 (B) 293T whole cell lysates.

Anti-PITX3 antibody [EPR8868] - ab134920 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8868
All lanes : Anti-PITX3 antibody [EPR8868] (ab134920) at 1/1000 dilutionLane 1 : 293T cell lysateLane 2 : Y79 cell lysateLane 3 : U87-MG cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat-anti-rabbit HRP at 1/2000 dilutiondeveloped using the ECL technique

Anti-PITX3 antibody [PPJ0069] - ab41975 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone PPJ0069

Anti-PITX3 antibody - Neuronal Marker - ab30734 from Abcam

Prices $380.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PITX3 antibody - Neuronal Marker (ab30734) at 1 µg/ml (5% Milk block)Lane 1 : Y79 (Human retinoblastoma cell line) Whole Cell Lysate Lane 2 : U-87 MG (Human glioblastoma astrocytoma) Whole Cell LysateLane 3 : HEK293 (Human embryonic kidney cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutionPerformed under reducing conditions.

Anti-PITX3 Antibody - LS-C17511 from LifeSpan Bioscience

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-PITX3 Antibody (aa110-124) - LS-C17509 from LifeSpan Bioscience

Prices $485.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-PITX3 Antibody (N-Terminus) - LS-C345696 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of PITX3 Antibody with human NCI-H226 Whole Cell lysate.

Anti-PITX3 Antibody (aa144-193) - LS-C101425 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PITX3 antibody LS-C101425 Western blot of Fetal Liver lysate.

Anti-PITX3 Antibody (aa29-40) - LS-C55291 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (1 ug/ml) staining of Human Cerebellum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-PITX3 Antibody (Internal, clone EPR8868) - LS-C154694 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8868
Western blot analysis on (A) 293T, (B) Y79, and (C) U87-MG cell lysates using anti-PITX3 antibody.

Anti-PITX3 Antibody (N-Terminus) IHC-plus™ - LS-B2606 from LifeSpan Bioscience

Prices $395.00
Sizes 25 µg
Host Rabbit
Clonality Polyclonal
Anti-PITX3 antibody IHC of human brain, cortex, white matter. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2606 concentration 5 ug/ml.

Anti-PITX3 Antibody (N-Terminus) IHC-plus™ - LS-B6679 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PITX3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6679 concentration 5 ug/ml.

Anti-PITX3 Antibody (N-Terminus) IHC-plus™ - LS-B994 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PITX3 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B994 concentration 5 ug/ml.

PITX3 Antibody - NBP1-92274 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PITX3 Antibody [NBP1-92274] - Analysis in human cell line RH-30.

PITX3 Antibody - NB100-96910 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: PITX3 Antibody [NB100-96910] - (1ug/ml) staining of Human Cer(35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

PITX3 Antibody - NBP1-39489 from Novus Biologicals

Prices $399.00
Sizes 25 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: PITX3 Antibody [NBP1-39489] - Staining of human brain, cortex, white matter. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

Anti-PITX3, (N-terminal) antibody produced in rabbit - SAB2103393 from Sigma-Aldrich

Prices $347.50
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PITX3, (N-terminal): <B>Cat. No. SAB2103393</B>: Immunohistochemistry of PITX3 in Testis tissue with PITX3 antibody at 4-8 μg/mL.

Anti-PITX3 antibody produced in rabbit - SAB2101815 from Sigma-Aldrich

Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PITX3: <B>Cat. No.SAB2101815</B>: PITX3 in Fetal Liver tissue lysate with PITX3 antibody at 1.0 μg/mL.

Anti-PITX3 antibody produced in rabbit - AV38544 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: HepG2 (<B>Cat. No. AV38544</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 0.5 μg/mL in cell type HepG2

Anti-PITX3 antibody produced in goat - SAB2500800 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PITX3: <B>Cat. No. SAB2500800</B>: (1 μg/mL) staining of Human Cerebellum lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-PITX3 antibody produced in rabbit - HPA044639 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PITX3: <B>Cat. No. HPA044639</B>: Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity, with a granular pattern in Purkinje cells.

PITX3 antibody - middle region (ARP33032_P050) - ARP33032_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PITX3 antibody - N-terminal region (ARP33033_P050) - ARP33033_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PITX3 antibody - N-terminal region (ARP38544_P050) - ARP38544_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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